Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders. (November 2020)

• Record Type: Journal Article
• Authors: Tyagi, Priya; Tasleem, Mohd; Prakash, Shweta; Chouhan, Garima
• Is Part Of: Food research international. Volume 137(2020)
• Publication Date: 2020-11
• Subjects: Probiotics -- Depression -- Gut microbes -- Psychobiotics -- Major depressive disorder -- Gut microbiota -- Depressive disorders -- Gut brain axis; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2020.109489
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Major Depressive disorder and comorbid neuropsychiatric conditions are leading cause of disability worldwide. Gut microbes have been shown to influence psychological state of hosts via different mechanisms. Gut dysbiosis is observed in depression and allied psychiatric conditions. Probiotic treatment can alleviate anxiety and depressive symptoms. Probiotic bacteria as psychobiotics can be alternative therapy for depression and associated disorders. Abstract: Depression is a debilitating psychiatric ailment which exerts disastrous effects on one's mental and physical health. Depression is accountable for augmentation of various life-threatening maladies such as neurodegenerative anomalies, cardiovascular diseases and diabetes. Depressive episodes are recurrent, pose a negative impact on life quality, decline life expectancy and enhance suicidal tendencies. Anti-depression chemotherapy displays marked adverse effects and frequent relapses. Thus, newer therapeutic interventions to prevent or combat depression are desperately required. Discovery of gut microbes as our mutualistic partner was made a long time ago and it is surprising that their functions still continue to expand and as of yet many are still to be uncovered. Experimental studies have revealed astonishing role of gut commensals in gut-brain signaling, immune homeostasis and hormonal regulation. Now, it is a well-established fact that gut microbes can alleviate stress or depression associated symptoms by modulating brain functions. Here in, we provide an overview of physiological alleyways involved in cross-talk between gut and brain, part played by probiotics in regulation of these pathways and use of probiotic bacteria as psychobiotics in various mental or depressive disorders.