Breast-milk derived potential probiotics as strategy for the management of childhood obesity. (November 2020)

• Record Type: Journal Article
• Authors: Oddi, S.; Huber, P.; Rocha Faria Duque, A.L.; Vinderola, G.; Sivieri, K.
• Is Part Of: Food research international. Volume 137(2020)
• Publication Date: 2020-11
• Subjects: Bifidobacterium -- Lactobacillus -- SHIME® -- Obesity -- Microbiota -- Alpha diversity -- Probiotic; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2020.109673
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Both strains increased the alpha diversity of the microbiota of an obese child. L. plantarum 73a and B. animalis subsp. lactis INL1 administration reduced the Proteobacteria phylum. The ammonium concentration was significantly reduced by the administration of L. plantarum 73a alone and combined to B. animalis subsp. lactis INL1. The taxonomy composition was significantly modified by the supplementation of L. plantarum 73a and B. animalis subsp. lactis INL1. Abstract: Obesity and overweight, and their concomitant metabolic diseases, emerge as one of the most severe health problems in the world. Prevention and management of obesity are proposed to begin early in childhood, when probiotics may have a role. The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), in a dynamic validated in vitro system able to simulate the different parts of the gastrointestinal tract, has proven to be useful in analyzing the human intestinal microbial community. L. plantarum 73a and B. animalis subsp. lactis INL1, two strains isolated from breast milk, were assayed in the SHIME® using the fecal microbiota of an obese child. L. plantarum 73a alone or in combination with B. animalis subsp. lactis INL1 demonstrated survival capacity in the SHIME® system. The administration of both strains increased the alpha diversity of the microbiota and reduced the levels of the phylum Proteobacteria. In particular, the genera Escherichia, Shigella, and Clostridium_sensu_stricto_1 were significantly reduced when both strains were administered. The increase of Proteobacteria phylum is generally associated with the microbiota of obese people. Escherichia and Shigella can be involved in inflammation-dependent adiposity and insulin resistance. L. plantarum 73a supplementation reduced ammonia production. L. plantarum 73a alone or in combination with B. animalis subsp. lactis INL1 are potential probiotic candidates for the management of infant obesity.