Weissella paramesenteroides WpK4 plays an immunobiotic role in gut-brain axis, reducing gut permeability, anxiety-like and depressive-like behaviors in murine models of colitis and chronic stress. (November 2020)

• Record Type: Journal Article
• Authors: Sandes, Sávio; Figueiredo, Naiara; Pedroso, Sílvia; Sant'Anna, Felipe; Acurcio, Leonardo; Abatemarco Junior, Mário; Barros, Patrícia; Oliveira, Fabrício; Cardoso, Valbert; Generoso, Simone; Caliari, Marcelo; Nicoli, Jacques; Neumann, Elisabeth; Nunes, Álvaro
• Is Part Of: Food research international. Volume 137(2020)
• Publication Date: 2020-11
• Subjects: Colitis -- Comorbidity -- Mood disorder -- Probiotics -- Psychobiotics; CEUA Institutional Ethics Committee on Animal Use (Comissão de Ética no Uso de Animais) -- Cpm represents the counts of radioactivity per minute -- Ct Control group, without challenge and treatment -- DAI disease activity index -- DSS Dextran sulfate sodium or mice challenged with DSS -- IDO1 Indoleamine 2, 3-dioxygenase 1 -- IBD Inflammatory bowel disease -- IRF Interferon-regulatory factor -- MyD88 Myeloid differentiation primary response 88 -- NLRP3 NLR family, pyrin domain containing 3 -- TLR toll-like receptors -- TRIF TIR-domain-containing adapter-inducing interferon-β -- WpK4 Weissella paramesenteroides WpK4 or mice treated with WpK4 -- WpK4Dss Colitis mice treated with WpK4 -- WpK4Stress Stressed mice treated with WpK4; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2020.109741
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Mood disorders could worsen the course of inflammatory bowel disease. In this study, we evaluated the role of a probiotic bacteria in the contexts of colitis and stress, separately. W. paramesenteroides WpK4 acted as an immunobiotic, reducing inflammation at local and systemic level, promoting gut barrier and reducing anxiety-like and depressive-like behaviors in mice. Highlights: In mice with colitis, WpK4 promoted the epithelial barrier, reducing gut leakage. WpK4 triggered Il22 expression, which could have contributed to mucosal healing. In stressed mice, WpK4 reduced anxiety-like and depressive-like behaviors. These beneficial effects could be related to an immunomodulation in gut and brain. Abstract: The relationship between inflammatory bowel disease (IBD) and mood disorders is complex and involves overlapping metabolic pathways, which may determine comorbidity. Several studies have been shown that this comorbidity could worsen IBD clinical course. The treatment of ulcerative colitis is complex, and involves traditional therapy to promote the function of epithelial barrier, reducing exacerbated inflammatory responses. Recently, it has been shown that some probiotic strains could modulate gut-brain axis, reducing depressive and anxiety scores in humans, including IBD patients. Accordingly, this study aimed to evaluate the role of Weissella paramesenteroides WpK4 in murine models of ulcerative colitis and chronic stress. It was observed that bacterium ingestion improved health of colitis mice, reducing intestinal permeability, besides improving colon histopathological appearance. In stressed mice, bacterial consumption was associated with a reduced anxiety-like and depressive-like behaviors. In both assays, the beneficial role of W. paramesenteroides WpK4 was related to its immunomodulatory feature. It is possible to state that W. paramesenteroides WpK4 exerted their beneficial roles in gut-brain axis through their immunomodulatory effects with consequences in several metabolic pathways related to intestinal permeability and hippocampal physiology.