Effect of polyphenols on HER2-positive breast cancer and related miRNAs: Epigenomic regulation. (November 2020)

• Record Type: Journal Article
• Authors: Zabaleta, María Eléxpuru; Forbes-Hernández, Tamara Yuliett; Simal-Gandara, Jesus; Quiles, José Luis; Cianciosi, Danila; Bullon, Beatriz; Giampieri, Francesca; Battino, Maurizio
• Is Part Of: Food research international. Volume 137(2020)
• Publication Date: 2020-11
• Subjects: Chemoresistance -- Mediterranean diet -- oncomiR -- tumor suppressor miR -- ErbB2 -- Antitumorigenic activity -- Prevention -- Low toxicity; BC Breast Cancer -- HER2 Human Epidermal Growth Factor 2 -- ER Estrogen Receptor -- PR Progesterone Receptor -- HR Hormone Receptor -- IHC Immunohistochemistry -- ISH In situ Hybridization -- EGFR Epidermal growth factor receptor -- FDA Food and Drug Administration -- ADC Antibody-drug conjugates -- TKI Tyrosine-kinase inhibitor -- ECD Extracellular Domain -- DFS disease-free survival -- ADCC antibody-dependent cellular cytotoxicity -- PFS progression-free survival -- OS Overall survival -- T-DM1 Trastuzumab-emtansine -- FASN Fatty acid synthase -- ChT Chemotherapy -- TIL Tumor-Infiltrating Lymphocytes -- PCR Pathologic Complete Response -- EGCG Epigallocatechin-gallate -- FOXO3 Forkhead box O3 -- EMT Epithelial-mesenchymal transition -- JAK-1 Janus kinase 1 -- GAE Gallic Acid Equivalent -- DHA Docosahexaenoic Acid -- PDC4 Programmed Cell Death 4 -- Sp Specific protein; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2020.109623
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Numerous HER2-breast cancer patients develop resistance to conventional therapies. Polyphenols from the Mediterranean diet have striking anti-carcinogenic properties. Dysregulation of micro-RNAs have been correlated with tumor development. Many polyphenols epigenetically regulate HER2-positive–related microRNAs. Polyphenols play a key role in HER2-breast cancer prevention by modulating microRNA. Abstract: HER2-positive breast cancer is one of the most aggressive subtypes accounting for nearly 30% of diagnosed cases. It is associated with reduced disease-free survival, tumor invasiveness, and a poor overall prognosis. Unfortunately, numerous patients develop resistance to conventional therapies; therefore, many ongoing clinical trials are testing new possible treatments. Polyphenols are the main bioactive components of the Mediterranean diet with multiple beneficial properties playing a key role in cancer prevention through epigenetic regulation. Aberrant variations in microRNAs levels regulating oncogenes or tumor suppressor genes expression may lead to tumor development. Evidence has shown that dietary polyphenols modulate HER2-positive breast cancer-associated microRNAs, resulting in a reduction of tumor growth and metastatic potential, and chemosensitivity restoration without displaying toxicity-derived adverse effects. These beneficial properties make polyphenols a potential therapeutic approach for HER2-positive breast cancer patients in the clinical setting, alone or in combination with conventional therapies.