Long-term supplementation with phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) reduces adiposophaty and improves glucose, lipid, and energy metabolism. (May 2021)

• Record Type: Journal Article
• Authors: Moura, Márcio H.C.; Donado-Pestana, Carlos M.; Rodrigues, Larissa; Pessoa, Erika V.M.; Rossi e Silva, Rafaela; Festuccia, Willian T.; Genovese, Maria Inés
• Is Part Of: Food research international. Volume 143(2021)
• Publication Date: 2021-05
• Subjects: Obesity -- Adiposophaty -- Insulin resistance -- NAFLD -- Polyphenols -- Jaboticaba; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2021.110302
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Polyphenols from jaboticaba (PEJ) were evaluated in mice with diet-induced obesity. PEJ decreased the body weight gain, adipocyte hypertrophy and inflammation. PEJ reduced hyperglycemia and insulin resistance and modulated the AKT/mTOR pathway. Hepatic steatosis and inflammation were ameliorated in PEJ-treated animals. PEJ increased energy expenditure of supplemented obese animals. Abstract: Obesity is a critical public health problem worldwide that has been associated to non-communicable diseases (NCD), such as type 2 diabetes (T2DM), non-alcoholic fatty lipid diseases (NAFLD) and inflammatory diseases. Polyphenols from several food sources have been studied as one option against these health problems. Sabara jaboticaba ( Plinia jaboticaba (Vell.) Berg) is a Brazilian berry rich in ellagic acid derivatives and anthocyanins. Here we investigated the effects of a phenolic-rich extract from Sabara jaboticaba (PEJ) in a diet-induced obesity animal model. PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) and 100 mg GAE/kg BW, were administered by daily gavage to obese C57BL/6J mice for 14 weeks. PEJ prevented the excessive body weight and adiposity, adipocyte hypertrophy, inflammation, hyperglycemia, glucose intolerance, insulin resistance, hypercholesterolemia, and hepatic lipid accumulation, as well as increased energy expenditure. In conclusion, polyphenols from Sabara jaboticaba presented several powerful therapeutic properties relevant for fighting obesity and associated health problems.