Anti-obesity properties and mechanism of action of flavonoids: A review. Issue 28 (3rd October 2022)

• Record Type: Journal Article
• Authors: Oliveira, Anne Karoline de Souza; de Oliveira e Silva, Ana Mara; Pereira, Raquel Oliveira; Santos, Andreza Santana; Barbosa Junior, Erivan Vieira; Bezerra, Mikaella Tuanny; Barreto, Rosana S. S.; Quintans-Junior, Lucindo J.; Quintans, Jullyana S. S.
• Is Part Of: Critical reviews in food science and nutrition. Volume 62:Issue 28(2022)
• Page Start: 7827
• Page End: 7848
• Publication Date: 2022-10-03
• Subjects: anti-obesity -- antioxidant -- anti-inflammatory -- flavonoids -- adipose tissue -- obesity; Food industry and trade -- Periodicals; Nutrition -- Periodicals; Nutrition -- Periodicals; Food -- Periodicals; Diet -- Periodicals; Review Literature -- Periodicals; Nutrition; Food; Diet; Review Literature; 664
• DOI: 10.1080/10408398.2021.1919051
• Languages: English
• ISSNs: 1040-8398

Abstract

Abstract: Obesity is a major public health problem, and there is increasing scientific interest in its mechanisms, as well as a search for new compounds with antioxidant and anti-inflammatory properties that can minimize the metabolic complications associated with its pathology. One potential source of these compounds is natural products; Among these, flavonoids are a promising group of natural substances. Flavonoids are active constituents with diverse biological activities and are widely found in plants kingdom. Numerous studies have shown that flavonoids can effectively inhibit obesity and related metabolic disorders. The review synthesizes recent evidence in respect of progress in the understanding of the anti-obesity effects of flavonoids. Such effects which occurs through the modulation of proteins, genes and transcriptional factors involved in decreasing lipogenesis, increasing lipolysis, expenditure energy, stimulating fatty acids B-oxidation, digestion and metabolism of carbohydrates. In addition to mitigating inflammatory responses and suppress oxidative stress. A better understanding of the modulating effects and mechanisms of flavonoids in relation to obesity will allow us to better use these compounds to treat or even prevent obesity and its associated comorbidities.