Bioactive properties and untargeted metabolomics analysis of bioaccessible fractions of non-fermented and fermented date fruit pomace by novel yeast isolates. (1st December 2022)

• Record Type: Journal Article
• Authors: Ayyash, Mutamed; Tarique, Mohammed; Alaryani, Maitha; Al-Sbiei, Ashraf; Masad, Razan; Al-Saafeen, Besan; Fernandez-Cabezudo, Maria; al-Ramadi, Basel; Kizhakkayil, Jaleel; Kamal-Eldin, Afaf
• Is Part Of: Food chemistry. Volume 396(2022)
• Publication Date: 2022-12-01
• Subjects: In vitro digestion -- Yeast -- Antioxidant -- Immunomodulatory -- Cytotoxicity; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133666
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Date fruit pomace (DFP) fermented by potential probiotic yeasts. Health-promoting benefits of the bioaccessible fraction were assessed. Untargeted metabolomics analysis was conducted to examine the bioaccessible fraction. Bioaccessible of fermented DFP exhibited high amylase inhibition and cytotoxicity. Abstract: In this study, attempts were made to utilize date by-product (date fruit pomace; DFP). This study aimed to investigate the health-promoting benefits of the fermented and non-fermented DFP before in vitro digestion and after (bioaccessible fraction). Untargeted metabolomic analyses for bioaccessible fractions were performed by UPLC-QTOF. DPPH percentages were 89.7%–90.3%, 90.1%–91.3%, and 90.8%–91.3% in the control, I. orientalis, and P. kudriazevii samples, respectively, before digestion; α-glucosidase inhibition before digestion was 1.9%–24.4%, 16.3%–30.0%, and 21.3%–31.3%, respectively; antimicrobial activities were 6.1%–13.3%, 13.7%–25.7%, and 20.6%–28.0% against E. coli O157:H7 and 2.2%–11.9%, 7.2%–20.7%, and 11.9%–29.2% against L. monocytogenes, respectively. The DPPH scavenging percentages were ∼63% lower in the bioaccessible fraction. The differentially regulated metabolites classes were benzene and derivatives, amino acids, peptides and analogs, organic acids, and phenols. This study revealed that the fermented DFP exhibited higher health properties than control.