4-Hydroxydibenzyl: a novel metabolite from the human gut microbiota after consuming resveratrol. Issue 14 (28th June 2022)

• Record Type: Journal Article
• Authors: Iglesias-Aguirre, C. E.; Vallejo, F.; Beltrán, D.; Berná, J.; Puigcerver, J.; Alajarín, M.; Selma, M. V.; Espín, J. C.
• Is Part Of: Food & function. Volume 13:Issue 14(2022)
• Page Start: 7487
• Page End: 7493
• Publication Date: 2022-06-28
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/d2fo01475k
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : 4-Hydroxydibenzyl is a novel metabolite produced by the human gut microbiota from resveratrol after sequential dehydroxylations at the 5- and 3-positions. Abstract : Resveratrol (RSV) was known to be metabolised by the gut microbiota to dihydroresveratrol, lunularin (LUNU), and (or) 3, 4′-dihydroxy- trans -stilbene (DHST). We describe here for the first time that LUNU can be further dehydroxylated, but only at the 3-position, to yield 4-hydroxydibenzyl, a novel metabolite found in human urine after RSV intake in 41 out of 59 healthy participants. In contrast, DHST was not further dehydroxylated, and thus, 4-hydroxy- trans -stilbene was not detected as a gut microbial metabolite of RSV. Faecal in vitro incubations confirmed the in vivo results.