Two Laminaria japonica polysaccharides with distinct structure characterization affect gut microbiota and metabolites in hyperlipidemic mice differently. (September 2022)

• Record Type: Journal Article
• Authors: Fang, Fang; Xiao, Chuqiao; Wan, Chu; Li, Yaqian; Lu, Xingyu; Lin, Ying; Gao, Jie
• Is Part Of: Food research international. Volume 159(2022)
• Publication Date: 2022-09
• Subjects: Mannogluconic acid (MA) -- Fucogalactan sulfate (FS) -- Metabolome -- Gut microbiota -- Hyperlipidemia; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2022.111615
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Dietary mannogluconic acid (MA) and fucogalactan sulfate (FS), with distinct structure characterization, affected differently on HFC-induced hyperlipidemia. FS with highly branched sugar residue and sulfate ester groups protected effectively against HFC-induced hyperlipidemia. FS increased the relative abundance of beneficial bacteria and the production of short-chain fatty acids (SCFAs). FS changed the metabolites associated with bile acid biosynthesis, which might contribute to synthesizing primary bile acid from cholesterol and thus decreasing the serum TC level. Abstract: Our previous study found dietary mannogluconic acid (MA) and fucogalactan sulfate (FS) from Laminaria japonica have distinct structure characterization and potential hypolipidemic effects in vitro . Herein, we compared the benefits of MA and FS on hyperlipidemia. The result showed only FS treatment decreased body weight and serum cholesterol levels. Compared with MA, FS was more effective in mitigating hepatic fat accumulation, promoting GSH-Px activity, reducing the MDA formation, and lowering the level of TNF-α in liver. Gut microbiota and metabolism analysis revealed that FS increased the relative abundance of beneficial bacteria and boosted the level of short chain fatty acids. Particularly, taurine and 3α, 7α, 12α-trihydroxy-24-oxo-5-β-cholestanoyl CoA were upregulated by FS, which might attribute to the increased Oscillibacter and thus affect the enterohepatic circulation of bile acids and serum TC level. Therefore, FS with more branches and sulfate ester groups could be a good lipid-lowering dietary supplement.