In silico modelling of protein digestion: A case study on solid/liquid and blended meals. (July 2022)

• Record Type: Journal Article
• Authors: Rivera del Rio, Andrea; van der Wielen, Nikkie; Gerrits, Walter J.J.; Boom, Remko M.; Janssen, Anja E.M.
• Is Part Of: Food research international. Volume 157(2022)
• Publication Date: 2022-07
• Subjects: In silico digestion -- Physiologically based models -- Compartmental models -- Protein digestion -- Gastric emptying -- Antral grinding; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2022.111271
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Mass balances were used to build a physiologically based model of protein digestion. Digestive processes were described by zero and first order differential equations. The biphasic nature of gastric emptying of solid/liquid meals can be predicted. The dynamic gastric pH and its effect on protein hydrolysis was simulated. Abstract: We present a dynamic, semi-mechanistic, compartmental protein digestion model to study the kinetics of protein digestion. The digestive system is described as a series of eight compartments: one for the stomach, one for the duodenum, two for the jejunum and four for the ileum. The digestive processes are described by a set of zero or first order differential equations. The model considers ingestion of a meal, secretion of gastric and pancreatic juices, protein hydrolysis, grinding, transit and amino acid absorption. The model was used to simulate protein digestion of a meal composed of a solid and a liquid phase or one where both phases are blended into a homogeneous phase. Luminal volumes and pH of gastric and duodenal contents were estimated for both meals. Further, gastric emptying is described as a function of the energy density of the bolus, instead of the more common mass action approach.