Hepatotoxicity of food-borne mycotoxins: molecular mechanism, anti-hepatotoxic medicines and target prediction. Issue 9 (30th March 2022)

• Record Type: Journal Article
• Authors: Ruan, Haonan; Lu, Qian; Wu, Jiashuo; Qin, Jiaan; Sui, Ming; Sun, Xinqi; Shi, Yue; Luo, Jiaoyang; Yang, Meihua
• Is Part Of: Critical reviews in food science and nutrition. Volume 62:Issue 9(2022)
• Page Start: 2281
• Page End: 2308
• Publication Date: 2022-03-30
• Subjects: Anti-hepatotoxic medicines -- hepatotoxicity -- molecular mechanism -- mycotoxins -- target prediction; Food industry and trade -- Periodicals; Nutrition -- Periodicals; Nutrition -- Periodicals; Food -- Periodicals; Diet -- Periodicals; Review Literature -- Periodicals; Nutrition; Food; Diet; Review Literature; 664
• DOI: 10.1080/10408398.2021.1960794
• Languages: English
• ISSNs: 1040-8398

Abstract

Abstract: Mycotoxins are metabolites produced by fungi. The widespread contamination of food and feed by mycotoxins is a global food safety problem and a serious threat to people's health. Most food-borne mycotoxins have strong hepatotoxicity. However, no effective methods have been found to prevent or treat Mycotoxin- Induced Liver Injury (MILI) in clinical and animal husbandry. In this paper, the molecular mechanisms and potential anti-MILI medicines of six food-borne MILI are reviewed, and their targets are predicted by network toxicology, which provides a theoretical basis for further study of the toxicity mechanism of MILI and the development of effective strategies to manage MILI-related health problems in the future and accelerate the development of food safety.