Gastrointestinal metabolism of monomeric and polymeric polyphenols from mango (Mangifera indica L.) bagasse under simulated conditions. (15th December 2021)

• Record Type: Journal Article
• Authors: Herrera-Cazares, Luz Abril; Ramírez-Jiménez, Aurea K.; Luzardo-Ocampo, Ivan; Antunes-Ricardo, Marilena; Loarca-Piña, Guadalupe; Wall-Medrano, Abraham; Gaytán-Martínez, Marcela
• Is Part Of: Food chemistry. Volume 365(2021)
• Publication Date: 2021-12-15
• Subjects: Mango (Mangifera indica L.) bagasse -- Bioaccessibility -- Principal component analysis -- Simulated gastrointestinal digestion; ABTS (PubChem CID: 9570474) -- Acetonitrile (PubChem CID: 6342) -- DPPH (PubChem CID: 74358) -- Ethyl acetate (PubChem CID: 8857) -- Formic acid (PubChem CID: 284) -- Hexane (PubChem CID: 8058) -- Methanol (PubChem CID: 997) -- Pentobarbital sodium (PubChem CID: 23676152) -- Sodium hydroxide (PubChem CID: 14798); 3G Trigalloyl hexoside -- 5G Pentagalloyl hexoside -- 6G Hexa-O-galloyl hexoside -- 7G Hepta-O-galloyl hexoside -- 8G Octa-O-galloyl hexoside -- ABTS 2, 2-azino-bis(3-ethylbenzothiazoline-6-sulfonic) acid -- AIF Absorbable intestinal fraction -- BIF Bioaccessible intestinal fraction -- CA Chlorogenic acid -- CIOMS Council for International Organizations of Medical Sciences -- DA Digallic acid -- DPPH 2, 2-diphenyl-1-picrylhydrazyl -- ER Efflux ratio -- GA Gallic acid -- GH Galloyl hexoside -- HPLC-DAD High-performance liquid chromatography coupled to diode array detector -- LC/MS-TOF-ESI Liquid chromatography coupled to mass spectrometry with a time of flight and electrospray ionization -- Man Mangiferin -- MB Mango bagasse -- MDH Maclurin di-O-galloyl-hexoside -- MG Methyl gallate -- MGE Methyl gallate ester -- MGH Maclurin mono-O-galloyl-hexoside -- Papp Apparent permeability coefficient -- PappA to B Apical to basolateral Papp -- PappB to A Basolateral to apical Papp -- PCA Principal component analysis -- QuerH Quercetin-3-O-hexoside -- SGD Simulated gastrointestinal digestion; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2021.130528
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Mango bagasse (MB) delivers bioaccessible phenolic compounds along with the digestion. Gallic acid, maclurin glucoside, and mangiferin were the main identified phenolics. Galloyl-hexoside/methyl gallate explained most of PCA variance during digestion. MB is a source of antioxidant and bioaccessible polyphenols. Abstract: Mango bagasse (MB) is an agro-industrial by-product rich in bioactive polyphenols with potential application as a functional ingredient. This study aimed to delineate the metabolic fate of monomeric/polymeric MB polyphenols subjected to simulated gastrointestinal digestion. The main identified compounds by LC/MS-TOF-ESI were phenolic acids [gallic acid (GA) and derivates, and chlorogenic acid], gallotannins and derivatives [di-GA (DA) and 3GG-to-8GG], benzophenones [galloylated maclurins (MGH, MDH)], flavonoids [Quercetin (Quer) and (QuerH)] and xanthones [mangiferin isomers]. The bioaccessibility depended on the polyphenols' structure, being Quer, 5G to 8G the main drivers. The results suggested that the gastrointestinal fate of MB polyphenols is mainly governed by benzophenones and gallotannins degalloylation and spontaneous xanthone isomerization in vitro to sustain GA bioaccessibility.