Advances in agaro-oligosaccharides preparation and bioactivities for revealing the structure-function relationship. (July 2021)

• Record Type: Journal Article
• Authors: Jiang, Chengcheng; Cheng, Danyang; Liu, Zhen; Sun, Jianan; Mao, Xiangzhao
• Is Part Of: Food research international. Volume 145(2021)
• Publication Date: 2021-07
• Subjects: Agar -- Agarase expression -- Agarose -- Agaro-oligosaccharides -- Biological activities; D-galactose D-Gal3, 6-anhydro-L-galactose -- L-AHG molecular weight -- MW neoagarooligosaccharide -- NAOS agarooligosaccharide -- AOS even-numbered AOSs -- EAOSs even-numbered NAOSs -- ENAOSs α-neoagarobiose hydrolase -- NABH odd-numbered AOSs -- OAOSs β-galactosidase -- ABG odd-numbered NAOSs -- ONAOSs degree of polymerization -- DP alkaline extraction -- AE microwave assisted extraction -- MAE enzyme extraction -- EE enzyme assisted extraction -- EAE hydrogen peroxide assisted enzymatic extraction -- HAEE trifluoroacetic acid -- TFA hydroxymethylfulfural -- 5-HMF agarotetraose -- A4 agarohexaose -- A6 agarooctaose -- A8 agarodecaose -- A10 agarobiose -- A2 neoagarotetraose -- NA4 neoagarobiose -- NA2 neoagarohexaose -- NA6 neoagarooctaose -- NA8 neoagarodecaose -- NA10 neoagarododecaose -- NA12 agarotriose -- A3 glycoside hydrolase -- GH agaroheptaose -- A7 agarononaose -- A9, A11 agaroundecaose -- A13 neoagarotetradecaose -- NA14 agaropentaose -- A5 signal peptide -- SP superoxide dismutase -- SOD glutathione peroxidase -- GPx reactive oxygen species -- ROS short chain fatty acids -- SCFAs nitric oxide -- NO prostaglandin E2 -- PGE2 tumor necrosis factor-α -- TNF-α interleukin-1β -- IL-1β interleukin-6 -- IL-6 lipopolysaccharide -- LPS oxygenase-1 -- HO-1 nuclear factor erythroid-2-related factor 2 -- Nrf2 c-jun N-terminal kinase -- JNK 2, 4, 6-trinitrobenzene sulfonic acid -- TNBS inflammatory bowel diseases -- IBD non-steroidal anti-inflammatory drugs -- NSAIDs mitogen-activated protein kinases -- MAPKs nuclear factor-κB -- NF-κB cyclooxygenase -- COX rheumatoid arthritis -- RA high-fat diet -- HFD cholesterol -- TC triglyceride -- TG free fatty acid -- FFA diet-induced obesity -- DIO fasting blood glucose -- FBG low-density lipoprotein cholesterol -- LDL-C high-density lipoprotein cholesterol -- HDL-C type 2 diabetes mellitus -- T2DM NAD(P)H quinone dehydrogenase-1 -- NQO1 peroxisome proliferator activated receptor-γ -- PPARγ high-cholesterol diet -- HCD LDL receptor -- LDLR sterol responsive element binding protein-2 -- SREBP-2 glycogen synthase kinase 3β -- GSK3β proprotein convertase subtilisin/kexin type 9 -- PCSK9 zonula occludens-1 -- ZO-1 adenosine monophosphate-activated protein kinase -- AMPK toll-like receptor 4 -- TLR4 6-hydroxydopamine -- 6-OHDA glutathione reductase -- GR hepatic alcohol dehydrogenase -- ADH natural killer -- NK myosin heavy chain -- MyHC α-melanocyte-stimulating hormone -- α-MSH human epidermal melanocytes HEMs; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2021.110408
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: The extraction methods of agar from red algae are summarized. The comparison of three methods for agaro-oligosaccharides production. The abundant bioactivities of agaro-oligosaccharides are described in detail. Agaro-oligosaccharides with different structures exhibit different bioactivities. Functional agaro-oligosaccharides play significant roles in human health. Abstract: Agaro-oligosaccharides originating from red algae have attracted increasing attention in both basic theoretical research and applied fields due to their excellent bioactivities, which indicates the wide prospects of agaro-oligosaccharides for application in the food, pharmaceutical and cosmetic industries. Thus, a considerable number of studies regarding functional agaro-oligosaccharides preparation as well as the bioactivities exploration have been carried out. Based on these studies, this review first introduced different methods that have been used in agar extraction from red algae, and further provided research progress on arylsulfatase. Then, different methods used for agaro-oligosaccharides production were summarized. Moreover, the abundant bioactivities of agaro-oligosaccharides were described in detail. Finally, this review has discussed current research problems and further provided critical aspects, which may be helpful for revealing the structure-function relationship of agaro-oligosaccharide.