Different effects of high-fat diets rich in different oils on lipids metabolism, oxidative stress and gut microbiota. (March 2021)

• Record Type: Journal Article
• Authors: Liu, Hechun; Zhu, Hangju; Xia, Hui; Yang, Xian; Yang, Ligang; Wang, Shaokang; Wen, Jingyuan; Sun, Guiju
• Is Part Of: Food research international. Volume 141(2021)
• Publication Date: 2021-03
• Subjects: Diet and dietary lipids -- Gut microbiome -- Fatty acids -- Oxidative stress -- Total cholesterol; ACC Acetyl coenzyme A carboxylase -- CAT Catalase -- CG Control group -- CRP C-reactive protein -- CVD Cardiovascular diseases -- E-in E-selectin -- ET-1 Endothelin-1 -- FAS Fatty acid synthase -- GM Gut microbiota -- GSH-Px Glutathione peroxidase -- HF High fat -- IL-6 Interleukin-6 -- LDA Linear discriminant analysis -- LEfse Line Discriminant Analysis Effect Size -- LO Lard oil -- MDA Malondialdehyde -- NMDS Nonmetric Multidimensional Scaling -- NO-1 Hemeoxygenase-1 -- NQO1 NAD (P) H dehydrogenase quinone 1 -- Nrf2 Nuclear factor (erythroid-derived 2)-like 2 -- OO Olive oil -- OTUs Operational taxonomic units -- PC Principal coordinate -- PCA Principal component analysis -- PCoA Principal coordinate analysis -- PGF-2 8-iso-prostaglandin E-2 -- PPARα Peroxisome proliferator-activated receptor α -- SFA Saturated fatty acid -- SO Soybean oil -- SOD Superoxide dismutase -- SREBP-1c Sterol regulatory element-binding protein-1c -- TC Total cholesterol -- TNF-α Tumor necrosis factor -- vWF Von Willebrand factor; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2020.110078
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: High-fat diets have the harmful effects on oxidative stress and lipid metabolism. High-fat diets can also cause gut microbiota dysbiosis. The Actinobacteria is link to the serum total cholesterol and malondialdehyde levels. Serum total cholesterol levels have negative correlations with Lactobacillales . Abstract: The study aimed to investigate the different effects of high-fat (HF) diets rich in different oils on lipid metabolism, oxidative stress, and gut mirobiota. C57BL/6 mice were divided into 4 groups: (1) control group (CG) was fed with normal diet, (2) olive oil (OO) group was fed with high-fat diet containing OO, (3) lard oil (LO) group was fed with high-fat diet containing LO, (4) soybean oil (SO) group was fed with high-fat diet containing SO. After 12 weeks, serum lipids, and oxidative stress indices were analyzed. Gut microbiota analysis was carried out based on the sequencing results of 16S rRNA. High fat diet can increase serum and liver lipids and upregulate sterol regulatory element-binding protein-1c related genes expression. Serum and liver malondialdehyde (MDA) levels in LO group were significantly higher than those in CG and OO groups. In CG, the family Muribaculaceae, Lactobacillaceae, Lachnospiraceae and Desulfovibrionaceae had the large effect sizes. HF diets resulted in the increase of Actinobacteria and Enterococcaceae abundance, and the decrease of Bacteroidetes, Proteobacteria Lactobacillales and microbiota diversity. The abundance of Actinobacteria and Lactobacillales is the link to the serum TC and MDA levels. HF diets have the harmful influence on the serum lipids, oxidative stress and endothelial function. They can also cause gut microbiota dysbiosis.