Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short‐Chain Fatty Acids. Issue 6 (6th February 2020)

• Record Type: Journal Article
• Authors: Robles‐Vera, Iñaki; Toral, Marta; de la Visitación, Néstor; Sánchez, Manuel; Gómez‐Guzmán, Manuel; Romero, Miguel; Yang, Tao; Izquierdo‐Garcia, José L.; Jiménez, Rosario; Ruiz‐Cabello, Jesús; Guerra‐Hernández, Eduardo; Raizada, Mohan K.; Pérez‐Vizcaíno, Francisco; Duarte, Juan
• Is Part Of: Molecular nutrition & food research. Volume 64:Issue 6(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-06
• Subjects: endothelial dysfunction -- gut microbiota -- hypertension -- immune system -- probiotic bacteria -- spontaneously hypertensive rats; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201900616
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: The objective of this study is to determine the cardiovascular effects of the probiotics Bifidobacterium breve CECT7263 (BFM) and Lactobacillus fermentum CECT5716 (LC40), and the short chain fatty acids butyrate, and acetate in spontaneously hypertensive rats (SHR). Methods and results: Ten five‐week old Wistar Kyoto rats (WKY) and fifty aged‐matched SHR are randomly distributed into six groups: control WKY, control SHR, treated SHR‐LC40, treated SHR‐BMF, treated SHR‐butyrate, and treated SHR‐acetate. Chronic treatments with LC40 or BFM increase butyrate‐producing bacteria and prevent the blood pressure increase in SHR. Oral treatment with butyrate or acetate also prevents the increase in both blood pressure and Firmicutes/Bacteroidetes (F/B) ratio. All treatments restore the Th17/Treg balance in mesenteric lymph nodes, normalized endotoxemia, and prevent the impairment of endothelium‐dependent relaxation to acetylcholine, as a result of reduced NADPH oxidase‐driven reactive oxygen species production. These protective effects might be mediated by both the reduction in vascular lipopolysaccharide (LPS)/toll‐like receptor 4 (TLR4) pathway and the increase in Treg infiltration in the vasculature. Conclusion: The probiotics LC40 and BFM prevent dysbiosis and the development of endothelial dysfunction and high blood pressure in genetic hypertension. These effects seem to be related to endotoxemia reduction and to increase Treg accumulation in the vasculature. Abstract : The probiotics LC40 and BFM prevent dysbiosis and the development of endothelial dysfunction and high blood pressure in genetic hypertension. This effect seems to be related to endotoxemia reduction, vascular TLR4 pathway impairment, and to increase Treg accumulation in the vasculature.