A critical review of antibiotic resistance in probiotic bacteria. (October 2020)

• Record Type: Journal Article
• Authors: Li, Ting; Teng, Da; Mao, Ruoyu; Hao, Ya; Wang, Xiumin; Wang, Jianhua
• Is Part Of: Food research international. Volume 136(2020)
• Publication Date: 2020-10
• Subjects: Probiotics -- Intrinsic antibiotic resistance -- Acquired antibiotic resistance -- Mechanism -- Potential risks -- Strategy; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2020.109571
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Probiotics have different physiological functions on immune and microecology. There are two types of probiotics resistance to antibiotics: intrinsic and acquired. Probiotics develop antibiotic resistance by gene mutation or horizontal gene transfer. Probiotics have potential risks-pathogenicity and antibiotic resistance gene transfer. Abstract: Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit upon the host. At present, probiotics are gaining popularity worldwide and are widely used in food and medicine. Consumption of probiotics is increasing with further in-depth research on the relationship between intestinal flora and host health. Most people pay more attention to the function of probiotics but ignore their potential risks, such as infection and antibiotic resistance transfer to pathogenic microbes. Physiological functions, effects and mechanisms of action of probiotics were covered in this review, as well as the antibiotic resistance phenotypes, mechanisms and genes found in probiotics. Typical cases of antibiotic resistance of probiotics were also highlighted, as well as the potential risks (including pathogenicity, infectivity and excessive immune response) and corresponding strategies (dosage, formulation, and administration route). This timely study provides an avenue for further research, development and application of probiotics.