Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties. (October 2020)

• Record Type: Journal Article
• Authors: Wu, Yujie; Mou, Bolin; Song, Shuang; Tan, Chin-Ping; Lai, Oi-Ming; Shen, Cai; Cheong, Ling-Zhi
• Is Part Of: Food research international. Volume 136(2020)
• Publication Date: 2020-10
• Subjects: Curcumin liposome -- Phospholipids -- Storage stability -- In-vitro digestibility -- Anti-oxidative -- Anti-hyperglycemic; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2020.109301
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: Curcumin liposomes were prepared using bovine milk and krill phospholipids. Curcumin liposomes produced from bovine milk phospholipids had higher storage stability. Liposomes from krill phospholipids had higher in-vitro digestibility and bioavailability. Phospholipids did not affect the antioxidative and antihyperglycemic of curcumin liposomes. Abstract: Present study prepared curcumin liposomes with high encapsulation efficiency (>70%) using bovine milk and krill phospholipids; and investigated the effects of phospholipids composition on storage stability, in-vitro bioavailability, antioxidative and anti-hyperglycemic properties of the curcumin liposomes. Curcumin liposomes prepared from bovine milk phospholipids have smaller particle sizes (163.1 ± 6.42 nm) and greater negative zeta potentials (−26.7 mv) as compared to that prepared from krill phospholipids (particle size: 212.2 ± 4.1 nm, zeta potential: −15.23 mv). In addition, curcumin liposomes from bovine milk phospholipids demonstrated better stability under harsh storage conditions (alkaline conditions, oxygen, high temperature and relative humidity). Nevertheless, curcumin-loaded liposomes prepared from bovine milk phospholipids have inferior bioavailability compared to that prepared from krill phospholipids. No significant differences can be observed in terms of anti-oxidative and anti-hyperglycemic properties of liposomes prepared from both bovine milk and krill phospholipids. Findings from present study will open up new opportunities for development of stable curcumin liposomes with good functional properties (high digestibility, bioavailability and pharmacological effects).