Effect of embryo-remaining oat rice on the lipid profile and intestinal microbiota in high-fat diet fed rats. (March 2020)

• Record Type: Journal Article
• Authors: Huang, Kai; Yu, Wenwen; Li, Sen; Guan, Xiao; Liu, Jing; Song, Hongdong; Liu, Dandan; Duan, Ruiqian
• Is Part Of: Food research international. Volume 129(2020)
• Publication Date: 2020-03
• Subjects: EROR -- Lipid metabolism regulation -- Hyperlipidemia -- SCFAs -- Intestinal microbiota; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2019.108816
• Languages: English
• ISSNs: 0963-9969

Abstract

Graphical abstract: Highlights: EROR is popular in China for its good taste, welcomed appearance and short cooking time. Ethanol extract of EROR could alleviate the lipid accumulation in OA induced HepG2 cells. EROR could dramatically modulate the lipid profile in serum and liver in HFD fed rats. Supplementation of EROR could significantly increase total SCFAs, acetate and propionate. EROR is beneficial for the regulation of intestinal microbiota dysbiosis against HFD. Abstract: Embryo-remaining oat rice (EROR), as a newly developed oat product, is popular in China for its good taste, but little is known about its healthy functions. In this study, the effects of EROR on lipid metabolism regulation were investigated in in vitro and in vivo models. The results showed that the oat ethanol extracts significantly alleviated lipid accumulation, total cholesterol and triglyceride levels in HepG2 cells. EROR supplementation dramatically improved the lipid profile in the serum and liver and downregulated the expression levels of HMGCR, SREBP-1C and FAS, which are related to lipid metabolic disorder in high-fat diet (HFD) fed rats. A HFD decreases the production of short-chain fatty acids (SCFAs) in the cecum, which are related to intestinal microbiota dysbiosis. The intake of EROR significantly increased the total SCFAs, acetate and propionate and promoted the abundance of SCFA-producing bacteria. Furthermore, the intake of EROR led to abundant increases in Bifidobacterium and Akkermansia and decreases of Rombutsia, Fusicatenibacter, Holdemanella and Turicibacter, which were negatively and positively correlated with the lipid metabolism-related indices. These results provide evidence that EROR is a good functional food candidate to ameliorate lipid metabolic disorder and hyperlipidemia.