Ethanolamine Produced from Oleoylethanolamide Degradation Contributes to Acetylcholine/Dopamine Balance Modulating Eating Behavior. Issue 3 (4th February 2019)

• Record Type: Journal Article
• Authors: Mennella, Ilario; Boudry, Gaëlle; Val-Laillet, David
• Is Part Of: Journal of nutrition. Volume 149:Issue 3(2019)
• Page Start: 362
• Page End: 365
• Publication Date: 2019-02-04
• Subjects: dopaminergic system -- N-acetylethanolamines -- fatty acid amide hydrolase -- γ-aminobutyric acid -- endocannabinoids -- neurotransmitters -- neurons -- neuromodulator; Nutrition -- Periodicals; Diet -- Periodicals; 613.205
• DOI: 10.1093/jn/nxy281
• Languages: English
• ISSNs: 0022-3166

Abstract

Abstract: Oleoylethanolamide is a well-recognized anorectic compound which also has noteworthy effects on food-reward, influencing the acetylcholine (ACh)/dopamine (DA) balance in the cholinergic system. After its administration, oleoylethanolamide is quickly degraded into oleic acid and ethanolamine. The effect of oleic acid on the gut–brain axis has been extensively investigated, whereas ethanolamine has received scarce attention. However, there is scattered evidence from old and recent research that has underlined the influence of ethanolamine on the cholinergic system. In the present article, we propose a model by which the released ethanolamine contributes to the overall balance between DA and ACh after oleoylethanolamide administration.