Population heterogeneity tactics as driving force in Salmonella virulence and survival. (November 2019)

• Record Type: Journal Article
• Authors: Staes, Ines; Passaris, Ioannis; Cambré, Alexander; Aertsen, Abram
• Is Part Of: Food research international. Volume 125(2019)
• Publication Date: 2019-11
• Subjects: Food-borne pathogen -- Salmonella -- Virulence factors -- Gene regulation -- Population heterogeneity -- Infection strategies; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2019.108560
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: Salmonella enterica comprises many pathogenic serovars that are able to colonize a variety of animal hosts and therefore constitute an important source of zoonotic food-borne illness. Their pathogenicity can range from gastroenteritis to typhoid fever, and depends on a series of virulence factors that are regularly located on laterally acquired genetic elements. The regulation of these virulence factors often also includes their differential expression within clonal populations. Moreover, exploitation of the resulting population heterogeneity appears to be an integral aspect of Salmonella virulence that could also affect its survival outside the host. This review therefore addresses how the regulation and heterogeneous expression of various virulence factors supports Salmonella 's success as a food-borne pathogen . Highlights: Salmonella enterica heterogeneously expresses virulence factors. Their heterogeneous expression creates phenotypically diverse subpopulations. The different subpopulations enable intricate population-level strategies. These strategies are elementary for S. enterica infection and environmental survival.