Cyanidin-3-o-glucoside liposome: Preparation via a green method and antioxidant activity in GES-1 cells. (November 2019)

• Record Type: Journal Article
• Authors: Liang, Tisong; Guan, Rongfa; Quan, Zhao; Tao, Qingfeng; Liu, Zhenfeng; Hu, Qiang
• Is Part Of: Food research international. Volume 125(2019)
• Publication Date: 2019-11
• Subjects: C3G -- C3G liposomes -- GES-1cells -- Antioxidant activity -- Color stability -- Mitochondria structure; C3G Cyanidin-3-O-glucoside -- FBS Fetal Bovine Serum -- PC Phosphatidylcholine -- CH Cholesterol -- TEM Transmission electron microscope; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2019.108648
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: Cyanidin-3-O-glucoside (C3G) liposomes was used to improve the stability and antioxidant activity of C3G through a green thin-film dispersion method. The characteristics, stability and the effect of C3G liposomes on GES-1 cells were explored. Results showed that the particle size and encapsulation efficiency (EE%) of C3G liposomes were 258.9 ± 5.06 nm and 77.5%, respectively. DPPH assay showed that liposomes encapsulation can improve the antioxidant of C3G, while the ABTS assay was opposite. Stability study showed the C3G liposome were unstable under extended storage time. The effects of C3G liposomes on GES-1 cells showed that C3G liposomes can decrease the ROS levels of GES-1 and had negligible effects on cell viability and mitochondrial structure. These findings suggested that liposomes could be used as a carrier system to improve the stability of C3G. Graphical abstract: Unlabelled Image Highlights: Morphology and stability of C3G liposome were evaluated during 2 weeks storage. The effects of C3G liposome on GES-1 cells were explored by cell viability and mitochondria structure. The antioxidant activity of C3G liposome were determined by DPPH assay and ROS level.