Elaboration of curcumin-loaded rice bran albumin nanoparticles formulation with increased in vitro bioactivity and in vivo bioavailability. (April 2018)

• Record Type: Journal Article
• Authors: Liu, Chun; Yang, Xiaoquan; Wu, Wei; Long, Zhao; Xiao, Huaxi; Luo, Feijun; Shen, Yingbin; Lin, Qinlu
• Is Part Of: Food hydrocolloids. Volume 77(2018)
• Page Start: 834
• Page End: 842
• Publication Date: 2018-04
• Subjects: Rice bran albumin -- Curcumin -- Nanoparticles -- Bioactivity -- Bioavailability; Ethanol (PubChem CID: 702) -- Curcumin (PubChem CID: 969516); Hydrocolloids -- Periodicals; Food additives -- Periodicals; Colloïdes -- Périodiques; Aliments -- Additifs -- Périodiques; Colloids; Food additives; Periodicals; Electronic journals; 664.06
• DOI: 10.1016/j.foodhyd.2017.11.027
• Languages: English
• ISSNs: 0268-005X

Abstract

Abstract: Curcumin, a yellow pigment present in the spice turmeric ( Curcuma longa ), has been linked with various bioactivities, but its optimum potential is limited by its lack of dispersibility in aqueous solvents and poor oral bioavailability. Here, we employed a protein-based nanoparticle approach to improve bioactivity and bioavailability. Curcumin was encapsulated with 95.94% efficiency in biodegradable nanoparticulate formulation based on rice bran albumin (RBA). The mean particle diameter and ζ -potential of curcumin-loaded RBA nanoparticles (Cur-RBA-NPs) were 120 nm and −36.3 mV, respectively. The in vitro bioactivity and in vivo bioavailability of Cur-RBA-NPs were evaluated. The results indicated that the in vitro bioactivities (antioxidant activity, anti-inflammatory activity, and anti-proliferative activity on tumor cells) of Cur-RBA-NPs were superior to those of free curcumin, respectively. Moreover, Cur-RBA-NPs significantly enhanced the bioavailability of curcumin in rats as compared with free curcumin. Besides, the results clearly indicated the promise of RBA-based nanoparticles for oral delivery of poorly bioavailable molecules like curcumin. Graphical abstract: Image Highlights: Curcumin was encapsulated with 95.94% efficiency in biodegradable nanoparticulate formulation based on rice bran albumin. The in vitro bioactivities of Cur-RBA-NPs were superior to those of free curcumin. Cur-RBA-NPs significantly enhanced the bioavailability of curcumin in rats as compared with free curcumin.