Structures, bioactivities and future prospective of polysaccharides from Morus alba (white mulberry): A review. (15th April 2018)

• Record Type: Journal Article
• Authors: He, Xirui; Fang, Jiacheng; Ruan, Yinlan; Wang, Xiaoxiao; Sun, Yin; Wu, Ni; Zhao, Zefeng; Chang, Yu; Ning, Ning; Guo, Hao; Huang, Linhong
• Is Part Of: Food chemistry. Volume 245(2018)
• Page Start: 899
• Page End: 910
• Publication Date: 2018-04-15
• Subjects: ABTS 2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) -- AG II arabinogalactans type II -- Akt protein kinase B -- Bcl-2 B-cell lymphoma-2 -- BMDC bone-marrow-derived dendritic cell -- cAMP cyclic adenosine monophosphate -- CAT catalase -- CMPS cationic M. alba leaf polysaccharides -- DCs dendritic cells -- ERK extracellular signal-related kinases -- FBG fasting blood glucose -- FRAP ferric-reducing antioxidant power -- GLUT4 glucose transporter type 4 -- GPx glutathione peroxidase -- GSH-Rd glutathione reductase -- GSP glycosylated serum protein -- HDL-C high-density lipoprotein cholesterol -- IFN-β interferon-β -- IFN-γ interferon-γ -- IL interleukin -- iNOS inducible nitric oxide synthase -- IRSs insulin receptor substrates -- JNK c-Jun N-terminal kinase -- LPS lipopolysaccharide -- MAPK mitogen-activated protein kinase -- MDA malondialdehyde -- MnSOD manganese superoxide dismutase -- MLPs M. alba leaf polysaccharides -- MFPs M. alba fruit polysaccharides -- MP an isolated M. alba fruit glycoprotein -- MRPs M. alba branch polysaccharides -- MCPs M. alba root bark polysaccharides -- MHC major histocompatibility complex -- NK natural killer -- NO nitric oxide -- PARP poly (ADP-ribose) polymerase -- PDX-1 pancreatic duodenal homeobox-1 -- p-ERK phosphor-extracellular regulated protein kinases -- pTGF-β1 plasmid transforming growth factor β1 -- RG-I rhamnogalacturonan type I -- PI3K phosphatidylinositol 3-kinase -- STZ streptozocin -- T2DM type 2 diabetes mellitus -- TC total cholesterol -- TG triglyceride -- TNF-α tumor necrosis factor-α; Medicinal and edible -- Mori Folium -- Mori Fructus -- Mori Ramulus -- Mori Cortex; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.11.084
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: M. alba is distinguished as a source of traditional medicines and functional foods. MLPs and MFPs have been well-studied over the past twenty years. M. alba polysaccharides possess promising antidiabetic and immunomodulatory properties. How potent the hypoglycemic health benefits of MFPs and MLPs in humans is unclear. Abstract: Morus alba L. (family Moreaceae), also known as white mulberry, is distinguished as a source of highly promising traditional medicines (including Mori Folium, Mori Fructus, Mori Ramulus and Mori Cortex) and also functional foods. Over the past two decades, the vast majority of the studies with regard to the isolation and bioactivities of M. alba polysaccharides have mainly focused on its leaves and fruits, which are both medicinal and edible. The tender M. alba leaf is edible and can be used to make tea, the mature M. alba fruit is sweet and juicy. M. alba fruits and leaves contain rich bioactive polysaccharides, which are shown to possess various promising bioactivities, mainly including antidiabetic, immunomodulation, anti-inflammation, antioxidation, anti-obesity, hepatoprotection and renoprotection. The main purpose of this review is to provide systematically reorganized information on structural characteristics and bioactivities of M. alba polysaccharides to support their further therapeutic potentials and sanitarian functions.