Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis. (September 2019)

• Record Type: Journal Article
• Authors: Romualdo, Guilherme Ribeiro; Rocha, Ariane Bartolomeu; Vinken, Mathieu; Cogliati, Bruno; Moreno, Fernando Salvador; Chaves, María Angel García; Barbisan, Luis Fernando
• Is Part Of: Food research international. Volume 123(2019)
• Page Start: 567
• Page End: 589
• Publication Date: 2019-09
• Subjects: Espresso and common coffee -- Caffeine -- Trigonelline -- Chlorogenic acid -- Gastrointestinal cancer -- Liver cancer; 4-NQO 4-Nitroquinoline-1-oxide -- AC Adenocarcinoma -- ACF Aberrant crypt foci -- Ad-PTEN Adenovirus-mediated transfer of phosphatase and tensin homolog -- AhR Aryl hydrocarbon receptor -- Akt Protein kinase B -- AOM Azoxymethane -- ARE/XRE Antioxidant/xenobiotic response elements -- BSA Body surface area -- CCl4 Carbon tetrachloride -- COX-2 Cyclooxygenase 2 -- CQA Caffeoylquinic acid -- CRC Colorectal cancer -- CTGF Connective tissue growth factor -- CYP Cytochrome P450 -- DEN Diethylnitrosamine -- DMBA 7, 12-Dimethylbenz[a]anthracene -- DMH 1, 2-Dimethylhydrazine hydrochloride -- DSS Dextran sulphate sodium -- EFSA European Food Safety Authority -- EGR1/mPGES-1 Early growth response protein-1/microsomal Prostaglandin E Synthase-1 -- EMT Epithelial-mesenchymal transition -- ERK Extracellular signal-regulated kinase -- G6Pase Glucose 6-phosphatase -- GCLC Glutamate-cysteine ligase catalytic subunit -- GR Glutathione reductase -- GSH Reduced glutathione levels -- GSH-Px Glutathione peroxidase -- GST-P Placental glutathione-S-transferase -- HCV/HBV Hepatitis B/C virus -- HCC Hepatocellular carcinoma -- HED Human equivalent dose -- HFD High fat diet -- HIF-1α Hypoxia-inducible factor-1α -- HSCs Hepatic stellate cells -- HWM High molecular weight -- IARC International Agency for Research on Cancer -- IBD Inflammatory bowel disease -- IFNγ Interferon-γ -- IRE1-α Inositol-requiring enzyme 1 alpha -- IL Interleukin -- MAM Methylazoymethanol -- miRs microRNAs -- MDA Malondialdehyde -- MEK1 Mitogen-activated protein kinase 1 -- MMP Matrix metalloproteinase -- MNNG N-Methyl-N′-nitro-N-nitrosoguanidine -- MNU N-Methyl-N-nitrosourea -- NAFLD Non-alcoholic fatty liver disease -- NF-κB Nuclear fator κB -- NMBA N-Nitrosomethylbenzylamine -- NQO1 NAD(P)H quinone dehydrogenase 1 -- Nrf2 Nuclear factor erythroid-related factor 2 -- OR Odds ratio -- PA Palmitic acid -- PCNA Proliferating cell nuclear antigen -- PGE2 Prostaglandin E2 -- PhIP 2-Amino-1-methyl-6-phenylimidazo[4]=5-[b]pyridine -- PKCα Protein kinase Cα -- PNL Preneoplastic lesions -- PPARγ Peroxisome proliferator-activated receptor gamma -- ROS Reactive oxygen species -- RR Relative risk -- SCC Squamous cell carcinoma -- SREBP1 Sterol regulatory element-binding protein 1 -- TAA Thioacetamide -- t-BOOH Tert-butylhydroperoxide -- TGF-β Transforming growth factor β -- TIMP Tissue inhibitor of metalloproteinase -- TNF-α Tumor necrosis factor α -- TOPK T-LAK Cell-originated protein -- UGT UDP Glucuronosyltransferases -- VEGF Vascular endothelial growth factor.; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2019.05.029
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: Recent meta-analyses indicate that coffee consumption reduces the risk for digestive tract (oral, esophageal, gastric and colorectal) and, especially, liver cancer. Coffee bean-derived beverages, as the widely-consumed espresso and "common" filtered brews, present remarkable historical, cultural and economic importance globally. These drinks have rich and variable chemical composition, depending on factors that vary from "seeding to serving". The alkaloids caffeine and trigonelline, as well as the polyphenol chlorogenic acid, are some of the most important bioactive organic compounds of these beverages, displaying high levels in both espresso and common brews and/or increased bioavailability after consumption. Thus, we performed a comprehensive literature overview of current knowledge on the effects of coffee beverages and their highly bioavailable compounds, describing: 1) recent epidemiological and experimental findings highlighting the beneficial effects against gastrointestinal/liver carcinogenesis, and 2) the main molecular mechanisms in these in vitro and in vivo bioassays. Findings predominantly address the protective effects of coffee beverages and their most common/bioavailable compounds individually on gastrointestinal and liver cancer development. Caffeine, trigonelline and chlorogenic acid modulate common molecular targets directly implicated in key cancer hallmarks, what could stimulate novel translational or population-based mechanistic investigations. Graphical abstract: Unlabelled Image Highlights: Caffeine, chlorogenic acid and trigonelline are major compounds of coffee drinks. Coffee lowers gastrointestinal and, especially, liver cancer risk in humans. Coffee/major compounds attenuate gastrointestinal and liver carcinogenesis in vivo. Major compounds share many cancer hallmark-related molecular targets in vitro. Interaction of major compounds must be considered for future translational assays.