Chinese yam (Dioscorea opposita Thunb.) alleviates antibiotic-associated diarrhea, modifies intestinal microbiota, and increases the level of short-chain fatty acids in mice. (August 2019)

• Record Type: Journal Article
• Authors: Zhang, Nan; Liang, Tisong; Jin, Quan; Shen, Cai; Zhang, Yifan; Jing, Pu
• Is Part Of: Food research international. Volume 122(2019)
• Page Start: 191
• Page End: 198
• Publication Date: 2019-08
• Subjects: Chinese yam -- Antibiotic-associated diarrhea -- Intestinal bacteria -- Short-chain fatty acids -- DGGE; Allantoin (PubChem CID: 204); Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2019.04.016
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: Antibiotic-associated diarrhea (AAD) is a common adverse effect of antibiotic treatment. The study was to evaluate effects of Chinese yam ( Dioscorea opposita Thunb.) on AAD, and changes of intestinal microbiota and short-chain fatty acids (SCFA). AAD model was established using Balb/c mice by gavage with ampicillin for 5 days, followed by a 10-day administration of low, medium, and high dosage of Chinese yam, containing allantoin (4.35 mg/g) and polysaccharides (85.51 mg/g). The results showed that Chinese yam accelerated the recovery from acute diarrhea, reverse AAD-induced body weight loss and cecal enlargement. The high-dosage Chinese yam increased probiotic Bifidobacteria and Lactobacilli by 47% and 21% and decreased potential pathogen Enterococcus and Clostridium perfringens by 8% and 27% on day 15 ( P < .05). Bacterial community analysis revealed that Chinese yam contributed to repair the ampicillin-induced intestinal microbiota disorder, enrich the abundance of Bacteroides spp. and Clostridium spp. Additionally, Chinese yam supplementation increased the production of SCFA. Graphical abstract: Unlabelled Image Highlights: Supplementation of Chinese yam alleviated ampicillin-induced diarrhea. Chinese yam increased the amount of probiotic Bifidobacteria and Lactobacilli . Chinese yam promoted the recovery of bacterial community diversity. Chinese yam promoted the production of propionate, butyrate, and valerate.