Recent advances in the development of sesquiterpenoids in the treatment of type 2 diabetes. (June 2019)

• Record Type: Journal Article
• Authors: Chen, Lei; Lu, Xu; El-Seedi, Hesham; Teng, Hui
• Is Part Of: Trends in food science & technology. Volume 88(2019)
• Page Start: 46
• Page End: 56
• Publication Date: 2019-06
• Subjects: β-Cell dysfunction -- Insulin resistance -- Sesquiterpenoids -- Type 2 diabetes -- Key enzyme; Food industry and trade -- Periodicals; Food -- Biotechnology -- Periodicals; 664.005
• DOI: 10.1016/j.tifs.2019.02.003
• Languages: English
• ISSNs: 0924-2244

Abstract

Abstract: Background: Treatment of type 2 diabetes mellitus (T2DM) through dietary terpenoids is receiving a promising interest and sesquiterpenoids' importance for food and pharmaceutical industries is mainly based on the existed scientific works. Scope and approach: Sesquiterpenoids might contribute to prevent or delay T2DM by inhibiting key enzymes relevant for hyperglycemia, modulating β-cells function, targeting insulin signaling route, etc. Sesquiterpenoids also have been demonstrated to stimulate glucose uptake by enhancing glucose transport, repressing glucose production, or improving lipid metabolism. Key findings and conclusions: In this review, we summarized the latest developments of sesquiterpenoids in the treatment of type 2 diabetes as well as sesquiterpenoids-rich herbs against key enzymes relevant to hyperglycemia, and discussed their underlying molecular mechanisms of anti-diabetic potential. We also suggested a better evaluation of the pharmacological profile of sesquiterpenoids and their derivate with a clear-cut choice of possible human pathologies. Highlights: Structural features of sesquiterpenoids are compared. The anti-type 2 diabetes of sesquiterpenoids are discussed. Potential health benefits of sesquiterpenoids are highlighted. Novel products and structure-activity relationship are discussed.