Antifungal and physicochemical properties of inclusion complexes based on β-cyclodextrin and essential oil derivatives. (July 2019)

• Record Type: Journal Article
• Authors: Herrera, Andrea; Rodríguez, Francisco J.; Bruna, Julio E.; Abarca, Romina L.; Galotto, María J.; Guarda, Abel; Mascayano, Carolina; Sandoval-Yáñez, Claudia; Padula, Marisa; Felipe, Fabiana Ramos Souza
• Is Part Of: Food research international. Volume 121(2019)
• Page Start: 127
• Page End: 135
• Publication Date: 2019-07
• Subjects: Inclusion complexes -- Beta-cyclodextrin -- Botrytis cinerea -- Molecular dynamics: Cinnamaldehyde -- Eugenol -- Entrapment efficiency -- Antifungal activity -- Active compound release; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2019.03.026
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: Inclusion complexes based on β-cyclodextrin (β-CD) and antimicrobial compounds, were prepared by co-precipitation method, and characterized by entrapment efficiency (EE), thermal analysis, X-ray diffraction, 1 H NMR spectroscopy, and water sorption. In addition, experiments associated to evaluate the effect of relative humidity on the release of active compounds and antifungal tests were performed. The analysis evidenced the encapsulation of active compounds into the β-CD structure with EE of 91 ± 4.1% and 66 ± 2.1% for β-CD/cinnamaldehyde and β-CD/eugenol complexes, respectively. Additionally, high relative humidities favored the release of active compounds from inclusion complexes. On the other hand, inclusion complexes were able to control the growth of B. cinerea, which was evidenced by a reduction of its mycelialradial growth. Finally, specific interactions between the active compounds and β-CD were evaluated through molecular dynamics simulation techniques. According to the obtained results, these complexes could be applied as additives in the design of antifungal packaging. Graphical abstract: Unlabelled Image Highlights: β-CD inclusion complexes were prepared by co-precipitation method. Differences in host-guest interactions were evidenced. Inclusion complexes evidenced antifungal activity against B. cinerea . Higher relative humidities favored the release of active compounds.