Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence. Issue 17 (22nd November 2018)

• Record Type: Journal Article
• Authors: Chen, Lei; Teng, Hui; Jia, Zhen; Battino, Maurizio; Miron, Anca; Yu, Zhiling; Cao, Hui; Xiao, Jianbo
• Is Part Of: Critical reviews in food science and nutrition. Volume 58:Issue 17(2018)
• Page Start: 2908
• Page End: 2924
• Publication Date: 2018-11-22
• Subjects: Flavonoids -- inflammation -- intracellular signaling pathways -- structure-activity relationship; Food industry and trade -- Periodicals; Nutrition -- Periodicals; Nutrition -- Periodicals; Food -- Periodicals; Diet -- Periodicals; Review Literature -- Periodicals; Nutrition; Food; Diet; Review Literature; 664
• DOI: 10.1080/10408398.2017.1345853
• Languages: English
• ISSNs: 1040-8398

Abstract

ABSTRACT: Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo . To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs.