Anti-inflammatory effects of newly synthesized α-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice. (July 2018)

• Record Type: Journal Article
• Authors: Dai, Zhuqing; Feng, Simin; Liu, Anna; Wang, Hong; Zeng, Xiaoxiong; Yang, Chung S.
• Is Part Of: Food research international. Volume 109(2018)
• Page Start: 350
• Page End: 357
• Publication Date: 2018-07
• Subjects: Colitis -- Anti-inflammatory -- α-GOSg -- Cyclooxygenase-2; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2018.04.054
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: α-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized α-galacto-oligosaccharide mixture (α-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both α-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by α-GOSg. The results showed that the newly synthesized α-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of α-GOSg in humans remains to be investigated. Graphical abstract: Highlights: Newly synthesized α-galacto-oligosaccharides (α-GOSg) alleviates colitis in mice. α-GOSg has comparable activities than raffinose family oligosaccharides. Anti-inflammatory effects of α-GOSg are associated with suppression of COX-2.