A novel delivery system dextran sulfate coated amphiphilic chitosan derivatives-based nanoliposome: Capacity to improve in vitro digestion stability of (−)-epigallocatechin gallate. (March 2015)

• Record Type: Journal Article
• Authors: Zou, Liqiang; Peng, Shengfeng; Liu, Wei; Chen, Xing; Liu, Chengmei
• Is Part Of: Food research international. Volume 69(2015)
• Page Start: 114
• Page End: 120
• Publication Date: 2015-03
• Subjects: Amphiphilic chitosan -- Nanoliposome -- Dextran sulfate -- EGCG -- In vitro digestion stability -- Sustaining release; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2014.12.015
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: A novel delivery system was developed by coating dextran sulfate (DS) on the surface of amphiphilic chitosan derivative nanoliposome (DCMC-NL) through electrostatic interaction. DS coated DCMC-NL (DS-DCMC-NL) exhibited larger average particle size, lower polydispersity index, and more negative zeta potential, compared with DCMC-NL. DS-DCMC-NL exhibited good in vitro digestion stability, with no obvious variations on particle size under gastrointestinal tract environment, while DCMC-NL immediately formed sediment after being mixed with simulated intestinal fluid (SIF). EGCG as a hydrophilic model drug was encapsulated in DS-DCMC-NL, with a high encapsulation efficiency (90.8%). EGCG loaded DS-DCMC-NL (EG-DS-DCMC-NL) exhibited a relative good sustaining release property. The degradation of EGCG during SIF was effectively slowed by the encapsulation with DS-DCMC-NL. This study expects to provide a promising carrier for further application of EGCG. Highlights: The cationic nanoliposome (DCMC-NL) was prepared using amphiphilic chitosan. A novel carrier was developed by coating dextran sulfate on DCMC-NL. The novel carrier exhibited good digestion stability during simulated intestinal fluid (SIF). DS-DCMC-NL exhibited a good (−)-epigallocatechin gallate (EGCG) sustaining release. EGCG stability in SIF was markedly enhanced by DS-DCMC-NL encapsulation.