Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica. Issue 5 (1st March 2015)

• Record Type: Journal Article
• Authors: Cuong, To Dao; Hung, Tran Manh; Lee, Joo-Sang; Weon, Kwon-Yeon; Woo, Mi Hee; Min, Byung Sun
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 5(2015)
• Page Start: 1129
• Page End: 1134
• Publication Date: 2015-03-01
• Subjects: Scutellaria indica -- Labiatae -- Flavonoid -- Anti-inflammatory activity -- RAW 264.7 cells; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2014.12.055
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Six new phenolics, scutellariosides A–F (1 –3, 5 –6, and8 ), together with six known compounds (4, 7, 9 –12 ) were isolated from the whole plant of Scutellaria indica (Labiatae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR. Their anti-inflammatory activities were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Among them, compounds10 –12 had inhibitory effects with IC50 values ranging from 7.2 to 27.8 μM. Compound12 reduced LPS-induced iNOS expression in a dose-dependent manner.