Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica. Issue 5 (1st March 2015) - Cuong, To Dao
Graphical abstract: Abstract: Six new phenolics, scutellariosides A–F (1 –3, 5 –6, and8 ), together with six known compounds (4, 7, 9 –12 ) were isolated from the whole plant of Scutellaria indica (Labiatae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR. Their anti-inflammatory activities were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Among them, compounds10 –12 had inhibitory effects with IC50 values ranging from 7.2 to 27.8 μM. Compound12 reduced LPS-induced iNOS expression in a dose-dependent manner.