Dietary fats and F2-isoprostanes: A review of the clinical evidence. Issue 18 (12th December 2017)

• Record Type: Journal Article
• Authors: Da Silva, Marine S.; Bilodeau, Jean-François; Julien, Pierre; Rudkowska, Iwona
• Is Part Of: Critical reviews in food science and nutrition. Volume 57:Issue 18(2017)
• Page Start: 3929
• Page End: 3941
• Publication Date: 2017-12-12
• Subjects: 8-iso-PGF2α -- clinical trial -- oxidative stress -- polyunsaturated fatty acids -- trans-fatty acids; Food industry and trade -- Periodicals; Nutrition -- Periodicals; Nutrition -- Periodicals; Food -- Periodicals; Diet -- Periodicals; Review Literature -- Periodicals; Nutrition; Food; Diet; Review Literature; 664
• DOI: 10.1080/10408398.2016.1196646
• Languages: English
• ISSNs: 1040-8398

Abstract

ABSTRACT: Evidence supports that a high dietary fat intake increases oxidative stress and the risk of diet-induced metabolic disorders such as obesity, diabetes and cardiovascular diseases. F2 -isoprostanes (F2 -isoP) are formed by the non-enzymatic oxidation of arachidonic acid and are widely used as reliable biomarkers of oxidative stress in clinical studies. Dietary fats may influence F2 -isoP levels, as they (1) are metabolic substrates for their formation, (2) modify the lipid composition of tissues, and (3) affect the plasma lipoprotein concentrations which are involved in F2 -isoP transport. This review examined the latest clinical evidence on how dietary fats can affect blood circulation and excretion of F2 -isoP in individuals with healthy or deteriorated metabolic profiles. Clinical studies reported that saturated or monounsaturated fat-rich diets did not affect F2 -isoP levels in adults with healthy or deteriorated metabolic profiles. Though, ω-3 polyunsaturated fatty acids decreased F2 -isoP levels in numerous studies, whereas trans-fatty acids raised F2 -isoP excretion. Yet, the reported heterogeneous results reveal important considerations, such as the health status of the participants, the biological fluids used to determine F2 -isoP, the analytical methods employed and the specific F2 -isoP isomers detected. Therefore, future clinical studies should be designed in order to consider these issues in the studies of the effects of fat intake on oxidative stress.