Current research, regulation, risk, analytical methods and monitoring results for nicarbazin in chicken meat: A perspective review. (September 2017)

• Record Type: Journal Article
• Authors: Bacila, Danniele Miranda; Feddern, Vivian; Mafra, Luciana Igarashi; Scheuermann, Gerson Neudí; Molognoni, Luciano; Daguer, Heitor
• Is Part Of: Food research international. Volume 99:Part 1(2017)
• Page Start: 31
• Page End: 40
• Publication Date: 2017-09
• Subjects: ADI acceptable daily intake -- bw body weight -- CCα limit of decision -- CCβ detection capability -- DNC 4-4-dinitrocarbanilide -- EFSA European Food Safety Authority -- ELISA enzyme-linked immunosorbent assays -- ESI electrospray ionization -- FCIAS flow cytometry immunoassays -- FPIAs fluorescence polarization immunoassays -- HDP 2-hydroxy-4, 6-dimethyl-pyrimidine -- HPLC high performance liquid chromatography -- IC50 inhibitory concentration 50% -- LC-MS liquid chromatography coupled to mass spectrometry -- LC-MS/MS liquid chromatography-tandem mass spectrometry -- LFDs lateral flow devices -- LOD limit of detection -- LOQ limit of quantification -- LSE liquid-solid extraction -- MAPA Ministry of Agriculture, Livestock and Food Supply -- MRL maximum residue level -- MU measurement uncertainty -- NRP National Residue Program -- NOEL no observed effect level -- PLE pressurized liquid extraction -- PNCRC National Plan of Residues and Contaminants Control -- QuEChERS quick, easy, cheap, effective, rugged and safe -- qToF quadrupole time-of-flight -- SPE solid phase extraction -- SPR surface plasmon resonance -- UHPLC ultra high performance liquid chromatography; Food safety -- DNC -- Maximum residue limit -- LC-MS/MS -- Immunoassay -- Litter reuse; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2017.07.011
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: This review presents up-to-date information about current research on nicarbazin, one of the most used anticoccidials in poultry production. The focus is to elucidate regulation concerning nicarbazin, limits for its residues in food, how maximum residue limits in different countries are calculated regarding edible chicken tissues and the possible implications in human health. Analytical methods to extract and quantify this residue, expressed as dinitrocarbanilide (DNC) are presented and discussed, including qualitative screening and quantitative/confirmatory analytical methods. Monitoring results and occurrence of DNC residues in chicken meat are discussed. Additionally, the causes of eventual chicken meat contamination and possible solutions to reduce or eliminate DNC residue in tissues are also presented. The paper concludes with perspectives, the current state of DNC residue analysis and suggestions for future research, especially considering the gap in the study of residue recycling effect due to continuous chicken litter use. Graphical abstract: Highlights: Nicarbazin is an anticoccidial widely used as feed additive in poultry industry. The maximum residue limits for chicken meat differ among regulatory agencies. Chromatography coupled to mass spectrometry is used to quantify nicarbazin residue. This review presents the residue monitoring program results in different countries. We discuss analytical performance and decision-making.