Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects. (October 2017)

• Record Type: Journal Article
• Authors: Roehrs, Miguel; Conte, Lisiane; da Silva, Dariane Trivisiol; Duarte, Thiago; Maurer, Luana Haselein; de Carvalho, José Antonio Mainardi; Moresco, Rafael Noal; Somacal, Sabrina; Emanuelli, Tatiana
• Is Part Of: Food research international. Volume 100 Part 1(2017)
• Page Start: 771
• Page End: 779
• Publication Date: 2017-10
• Subjects: ALT alanine amino transferase -- AST aspartate amino transferase -- BIX bixin -- CAT catalase -- GPx glutathione peroxidase -- HDL high density lipoprotein -- IL-1 interleukin-1 -- IL-6 interleukin-6 -- NBIX norbixin -- NFkB nuclear factor kappa B -- PPAR peroxisome proliferator activated receptor -- SOD superoxide dismutase -- TAC total antioxidant capacity -- TBARS thiobarbituric acid reactive species -- TC total cholesterol -- TG triacylglycerols -- TNF-α tumoral necrosis factor α -- TOS total oxidant status -- VLDL very low density lipoprotein; Bixin -- Norbixin -- Postprandial response -- Cholesterol -- Glycaemia -- Inflammatory cytokines; Food -- Analysis -- Periodicals; Food industry and trade -- Periodicals; Food industry and trade -- Canada -- Periodicals; Food Technology -- Periodicals; Food -- Periodicals; Food-Processing Industry -- Periodicals; Aliments -- Industrie et commerce -- Périodiques; Aliments -- Industrie et commerce -- Canada -- Périodiques; Aliments -- Recherche -- Périodiques; Food industry and trade; Canada; Periodicals; Electronic journals; 664.005
• DOI: 10.1016/j.foodres.2017.08.005
• Languages: English
• ISSNs: 0963-9969

Abstract

Abstract: The aim of this study was to evaluate the effect of annatto carotenoids intake associated to a single high-calorie meal (high fat and high carbohydrate) in postprandial biochemical, inflammatory and oxidative stress markers. Twelve healthy subjects (6 men, 6 women) were included in this randomised, controlled crossover study. Baseline blood samples were collected from fasting subjects that immediately received high-calorie meal without carotenoid (placebo) or containing 1.2 mg/kg bixin (BIX) or 0.06 mg/kg norbixin (NBIX). Blood samples were taken 60, 120 and 240 min after meal intake. NBIX intake did not affect biochemical blood markers but reduced the postprandial levels of inflammatory cytokines (IL-1, IL-6 and TNF-α) and lipid oxidation 60–120 min after meal. BIX only partially prevented postprandial-induced lipid oxidation. Results indicate that the intake of NBIX may be an alternative to reduce the postprandial inflammatory and oxidative stress responses to high-calorie meals. Graphical abstract: Highlights: Effects of annatto carotenoids associated to high-calorie meal in human subjects Bixin and norbixin did not change postprandial blood glucose, insulin or lipid levels. Norbixin reduced postprandial LDL and lipid oxidation and inflammatory cytokines. Norbixin increased postprandial activity of blood glutathione peroxidase. Bixin only partially prevented postprandial lipid oxidation.