Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba. Issue 6 (27th May 2016)

• Record Type: Journal Article
• Authors: Bai, Lu; Zhang, Hai; Liu, Qingchao; Zhao, Yong; Cui, Xueqin; Guo, Sen; Zhang, Li; Ho, Chi-Tang; Bai, Naisheng
• Is Part Of: Food & function. Volume 7:Issue 6(2016)
• Page Start: 2870
• Page End: 2877
• Publication Date: 2016-05-27
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c6fo00613b
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : The fruit of Ziziphus jujuba Mill., also called hongzao in Chinese, has a long history of cultivation in China. Abstract : The fruit of Ziziphus jujuba Mill., also called hongzao in Chinese, has a long history of cultivation in China. From the fruit of Z. jujuba, twenty-seven known compounds were isolated and identified as the main constituents of these fruits. They were 3- O -( trans-p -coumaroyl)-alphitolic acid (1 ), 3- O -( cis-p -coumaroyl)-alphitolic acid (2 ), 3β- O -( trans-p -coumaroyl)-maslinic acid (3 ), pomonic acid (4 ), 2-oxo-pomolic acid (5 ), benthamic acid (6 ), terminic acid (7 ), oleanic acid (8 ), betulinic acid (9 ), quercetin 3- O -rutinoside (10 ), quercetin 3- O -robinobioside (11 ), apigenin (12 ), traumatic acid (13 ), ( Z )-4-oxotetradec-5-enoic acid (14 ), 7( E )-9-keto-hexadec-7-enoic acid (15 ), 9( E )-11-oxo-octadecenoic acid (9CI) (16 ), and magnoflorine (27 ), etc . The HPLC fingerprint of Z. jujuba fruits was established at the same time. Compounds4, 5, 7, 11, 14, 15 and16 were isolated from Z. jujuba for the first time. Compound14 was isolated from the nature for the first time. Furthermore, cytotoxicity against four human tumor cell lines (MCF-7, A549, HepG2 and HT-29) of the isolated compounds (1–17 and27 ) was evaluated. Among these compounds, compounds1, 2, 3, 6, 7, 9 and12 had strong growth inhibitory effects on cancer cell lines. These results indicated that jujube extracts exhibited cytotoxicity on these cancer cell lines.