A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal?. Issue 15 (13th October 2017)

• Record Type: Journal Article
• Authors: Grosso, Giuseppe; Marventano, Stefano; Yang, Justin; Micek, Agnieszka; Pajak, Andrzej; Scalfi, Luca; Galvano, Fabio; Kales, Stefanos N.
• Is Part Of: Critical reviews in food science and nutrition. Volume 57:Issue 15(2017)
• Page Start: 3218
• Page End: 3232
• Publication Date: 2017-10-13
• Subjects: Prevention -- randomized controlled trials -- prospective cohort studies -- olive oil -- vegetables -- fruit -- legumes; Food industry and trade -- Periodicals; Nutrition -- Periodicals; Nutrition -- Periodicals; Food -- Periodicals; Diet -- Periodicals; Review Literature -- Periodicals; Nutrition; Food; Diet; Review Literature; 664
• DOI: 10.1080/10408398.2015.1107021
• Languages: English
• ISSNs: 1040-8398

Abstract

ABSTRACT: Many studies have reported that higher adherence to Mediterranean diet may decrease cardiovascular disease (CVD) incidence and mortality. We performed a meta-analysis to explore the association in prospective studies and randomized control trials (RCTs) between Mediterranean diet adherence and CVD incidence and mortality. The PubMed database was searched up to June 2014. A total of 17 studies were extracted and 11 qualified for the quantitative analysis. Individuals in the highest quantile of adherence to the diet had lower incidence [relative risk (RR): 0.76, 95% confidence intervals (CI): 0.68, 0.83] and mortality (RR: 0.76, 95% CI: 0.68, 0.83) from CVD compared to those least adherent. A significant reduction of risk was found also for coronary heart disease (CHD) (RR: 0.72, 95% CI: 0.60, 0.86), myocardial infarction (MI) (RR: 0.67; 95% CI: 0.54, 0.83), and stroke (RR: 0.76; 95% CI: 0.60, 0.96) incidence. Pooled analyses of individual components of the diet revealed that the protective effects of the diet appear to be most attributable to olive oil, fruits, vegetables, and legumes. An average reduced risk of 40% for the aforementioned outcomes has been retrieved when pooling results of RCTs. A Mediterranean dietary pattern is associated with lower risks of CVD incidence and mortality, including CHD and MI. The relative effects of specific food groups should be further investigated.