Isolation and identification of antioxidant and α-glucosidase inhibitory compounds from fruit juice of Nitraria tangutorum. (15th July 2017)

• Record Type: Journal Article
• Authors: Zhao, Jian-Qiang; Wang, Yan-Ming; Yang, Yan-Long; Zeng, Ying; Wang, Qi-Lan; Shao, Yun; Mei, Li-Juan; Shi, Yan-Ping; Tao, Yan-Duo
• Is Part Of: Food chemistry. Volume 227(2017)
• Page Start: 93
• Page End: 101
• Publication Date: 2017-07-15
• Subjects: 1, 1-Diphenyl-2-picrylhydrazyl radical (PubChem CID: 2735032) -- 2, 2′-Azino-di(3-ethyl-benzthiazoline sulphonic acid (PubChem CID: 9570474) -- Ascorbic acid (PubChem CID: 54670067) -- Acarbose (PubChem CID: 444254) -- 4-Nitrophenyl α-d-glucopyranoside (PubChem CID: 92930); Nitraria tangutorum -- Glucose-derived β-carbolines -- Antioxidants -- α-Glucosidase inhibitory; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.01.031
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: The phytochemical research on the fruit juice of Nitraria tangutorum was carried out. Sixteen alkaloids including four new glucose-derived β-carbolines were isolated. Ten non-alkaloids including a new compound were obtained. The biogenetic pathways of1 –8 were proposed. Antioxidant and α -glucosidase inhibitory activities of all isolates were tested. Abstract: Nitraria tangutorum Bor., having edible berries, is valued for reputed health benefits in Qinghai-Tibet plateau. The phytochemical research on the fruit juice of N. tangutorum led to the isolation of twenty-six compounds including five new compounds, tangutorids A–D (1, 2, 3a, and3b ), and (3 E, 5 E )-7- O -β-glucosyl-4-(2-methoxy-2-oxoethyl)hepta-3, 5-dienoic acid (15 ). The structures of these compounds were elucidated through comprehensive spectroscopic analyses. Tangutorids A–F were the first examples of glucose-derived β-carbolines from natural products. The biogenetic pathways of1 –8 were proposed to involve Pictet–Spengler reactions and described starting from the co-isolated tryptophan (10 ) and corresponding aldehydes. All isolates were evaluated for their antioxidant and α -glucosidase inhibitory activities. Compounds21, 22, and24 showed antioxidant activity with SC50 values ranging from 12.2 ± 1.9 to 30.4 ± 2.7 μg/mL, and compound1 showed strong α -glucosidase inhibitory effect with IC50 value of 63.3 ± 4.6 μg/mL.