Microbial sensing in fermentation : making sense of applied parameters /: making sense of applied parameters. (2018)

• Record Type: Book
• Further Information: Note: Satinder K. Brar, Ratul K. Das, Saurabh J. Sarma.
• Editors: Brar, Satinder Kaur; Das, Ratul Kumar, 1979-; Sarma, Saurabh Jyoti
• Contents: List of Contributors xi 1 Biochemical Aspects of Microbial Product Synthesis: a Relook 1; G. Gallastegui, A. Larrañaga, Antonio Avalos Ramirez, and Thi Than Ha Pham 1.1 Introduction 1 1.2 History of Industrial Production of Microbial Products 2 1.2.1 Advances of Biochemical Engineering and Their Effects on Global Market of Microbial Products 3 1.2.2 Importance of Microbial Sensing in Product Formation 6 1.3 Conclusion 7 Acknowledgments 8 References 8 2 Cellular Events of Microbial Production: Important Findings So Far 11; Devangana Bhuyan and Ratul Kumar Das 2.1 Introduction 11 2.2 Microbial Metabolism and Evolution of Metabolic Pathways 12 2.3 Microbial Fermentation 12 2.4 The Microbial Cellular Events 15 2.5 Cell Signalling in Microorganisms 19 2.6 Microbial Performance Under Stress Conditions 21 Acknowledgment 24 References 24 3 Microbial Metabolism in a Refined Carbon Source: Generalities 27; Vinayak Laxman Pachapur, Preetika Rajeev Kuknur, Satinder Kaur Brar, and Rosa Galvez-Cloutier 3.1 Introduction 27 3.2 Microbial Metabolism in Presence of Pure and Crude Substrate 29 3.3 Microbial Metabolism in Presence of Pure and Mixed Cultures 31 3.4 Microbial Metabolism in the Presence of Co‐Substrate 33 3.5 Microbial Metabolism in the Presence of Input Parameters 35 3.6 Microbial Metabolism in the Presence of Varying Fermentation Conditions 37 3.7 Pros and Cons of Refined Substrate for Metabolic Metabolisms 38 3.8 Conclusions 39 Acknowledgment 40 References 40 4 Non ‐ refined Carbon Sources and Microbial Performance 43; Guneet Kaur 4.1 Introduction 43 4.2 Non‐refined Carbon Sources: a Brief Account 43 4.3 Microbial Assimilation of Non‐Refined Carbon Sources 45 4.4 Microbial Sensing to Non‐Refined Carbon Sources 48 4.4.1 Microbial Metabolism and Regulatory Circuits 48 4.4.2 CCR Regulation of Carbon Uptake and Metabolism 51 4.5 Guiding Product Outcomes via Rewiring of Cellular Regulatory Circuit 53 4.5.1 Cellular Engineering in E. Coli for Bioprocessing of Non‐Refined Carbon Sources 54 4.5.2 Rewiring S. cerevisiae for Accumulation and Conversion of Non‐refined Carbon Sources 55 4.6 Conclusions 56 References 57 5 Cellular versus Biochemical Control over Microbial Products 61; Carlos S. Osorio-González, Krishnamoorthy Hegde, and Satinder Kaur Brar 5.1 Introduction 61 5.2 3 Hydroxy‐propionic Acid 62 5.3 Fumaric Acid 64 5.4 Itaconic Acid 65 5.5 Glucaric Acid 67 5.6 Butanol 68 5.7 Malic Acid 69 5.8 Gluconic Acid 71 5.9 Aminovalaric Acid 71 5.10 Glutamic Acid 73 5.11 Cadaverine (1, 5‐diaminopentane) 74 5.12 Conclusion 76 Acknowledgment 76 References 76 6 Pre ‐ Treatment of Alternative Carbon Source: How Does it Make Sense to Microorganism at Cellular Level? 89; Joseph Sebastian, Pratik Kumar, Krishnamoorthy Hegde, Satinder Kaur Brar, Mausam Verma, and Ratul Kumar Das 6.1 Introduction 89 6.2 Pre‐ Treated Carbon Source and Microbial Assimilation: Cellular and Biochemical Aspects 91 6.2.1 Alcohols 94 6.2.1.1 Bioethanol 94 6.2.1.2 Butanol and Acetone 96 6.2.2 Hydrogen 98 6.2.3 Methane/biogas 101 6.2.4 Organic Acids 103 6.3 Challenges of Inhibitory Hydrolysis Products and Strategic Solution 106 6.3.1 Inhibitory Products: Pretreatment Metabolites or By‐products 106 6.3.1.1 Aliphatic Compounds 106 6.3.1.2 Aromatic Compounds 107 6.3.1.3 Furan Aldehydes 108 6.3.2 Strategies to Control Inhibitory Effects 109 6.3.2.1 Biological Detoxification Strategy for the Inhibitors 110 6.3.2.2 Understanding the Mechanism of Microorganism Adaptation for The Detoxification of Inhibitory Compounds 110 6.3.2.2.1 Homeostasis 110 6.3.2.2.2 Enzymatic Detoxification 111 6.3.2.3 Physical and Chemical Detoxification Strategy for Inhibitors 112 6.3.3 Correlation (Synergistic Effects) of Inhibitory Compounds and their Detoxification 118 6.4 Conclusion 126 Acknowledgments 127 References 127 7 Microbial Metabolic Pathways in the Production of Valued ‐ added Products 137; Gilberto V. de Melo Pereira, Ana M. Finco, Luiz A. J. Letti, Susan Grace Karp, Maria G. B. Pagnoncelli, Juliana de Oliveira, Vanete Thomaz Soccol, Satinder Kaur Brar, and Carlos Ricardo Soccol 7.1 Introduction 137 7.2 Microbial Molecular Structure 138 7.3 Biomass Production 140 7.3.1 Single Cell Oil 140 7.3.2 Single Cell Protein 142 7.4 Enzymes 148 7.5 Biofuels 150 7.6 Alkaloids, Terpenoids, Polyketides and Flavonoids 153 7.7 Organic Acids 155 7.8 Rare Sugars 156 7.9 Conclusions 157 References 158 8 Communication for a Collective Response to Environmental Stress: Bacterial and Fungal Perspectives 169; Azadeh Kermanshahi Pour 8.1 Introduction 169 8.2 Quorum Sensing in Bacteria and the Related Phenotypes 172 8.3 Fermentation and Quorum Sensing in Bacteria 177 8.4 Quorum Sensing in Fungi and the Related Phenotypes 183 8.5 Fermentation and Quorum Sensing in Fungi 186 8.6 Quorum Sensing in Bacteria and Fungi: Similarities and Differences 188 Acknowledgment 189 References 189 9 Biochemical and Cellular Events in Controlling Microbial Performance: A Comparative Account 201; Shadab Ahmed, Shreyas Niphadkar, Somnath Nandi, Satya Eswari, Vishal Pandey, Aishwarya Shankapal, and Aishvarya Agrawal 9.1 Biochemical vs. Molecular Cues for Microbial Performances 201 9.1.1 Nutritional Parameters Optimization 201 9.1.2 Process Condition Optimization 202 9.1.3 Process Improvement by Using Batch and Fed‐Batch via Process and Modeling 203 9.1.4 Metabolic Engineering for Improving Microbial Performance 203 9.1.4.1 Metabolic Flux Balance Analysis 203 9.1.4.1.1 Constraint Based Flux Balance Analysis 203 9.1.4.1.2 Defining Biological Objective to Optimize a Phenotype 204 9.1.4.1.3 Applications of Flux Analysis 204 9.1.5 Strain Improvement for Microbial Performance 205 9.1.5.1 Mutagenesis for Strain Improvement 205 9.1.5.1.1 Physical Mutagenesis 205 9.1.5.1.2 Chemical Mutagenesis 206 9.1.5.1.3 Biological Mutagenesis 206 9.2 Sequential Evidences of Biochemical and Molecular Controlling Over Microbial Performances 206 9.3 Biochemically Influenced Molecular Events and Vice Versa 208 9.4 Facts at the Interface of Biochemical and Molecular Controlling: Products vs Applied Parameters 208 9.4.1 Sulfur‐Delivery into Biosynthetic Pathway 208 9.4.2 Synthetic Biochemistry Platform for Production of Glucose 212 9.4.3 Biochemical and Molecular Aspects of Metabolic Engineering Approaches 212 9.4.3.1 Engineering Regulatory Network 212 9.4.3.2 Heterologous Expression of Entire Gene Cluster 213 9.4.3.3 Rerouting Metabolic Pathway 213 9.4.3.4 Integration of Metabolic Engineering and Process Engineering 213 9.5 Conclusions 214 References 214 10 Qualitative vs. Quantitative Control Over Microbial Products 223; Rachna Goswami, Vijay Kumar Mishra, and Radhika Pilli 10.1 Introduction 223 10.2 Qual
• Edition: 1st
• Publisher Details: Chichester : Wiley Blackwell
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 664.024; Fermentation; Molecular microbiology
• Languages: English
• ISBNs: 9781119247975
• Related ISBNs: 9781119247982
• Notes: Note: Description based on CIP data; resource not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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