1. Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans. (3rd July 2021) Authors: Yue, Qin; Khojasteh, S. Cyrus; Cho, Sungjoon; Ma, Shuguang; Mulder, Teresa; Chen, John; Pang, Jodie; Ding, Xiao; Deese, Alan; Pellet, Jackson D.; Siebers, Nicholas; Joas, Lori; Salphati, Laurent; Ware, Joseph A. Journal: Xenobiotica Issue: Volume 51:Number 7(2021) Page Start: 796 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Absorption, metabolism, and excretion of taselisib (GDC-0032), a PI3K inhibitor, in rats, dogs, and humans. Issue 1 (January 2017) Authors: Ma, Shuguang; Salphati, Laurent; Srikumar, Srikumar; Takahashi, Ryan; Ding, Xiao; Pang, Jodie; Wang, Bing; Remarchuk, Travis; Hsu, Jerry; Hop, Cornelis (Marcel); Ware, Joseph A.; Khojasteh, S. Cyrus Journal: Drug metabolism and pharmacokinetics Issue: Volume 32:Issue 1(2017)Supplement Page Start: S74 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Can transporter-expressing cells predict rosuvastatin uptake clearance in suspended or plated human hepatocytes?. Issue 1 (January 2019) Authors: Kumar, Vineet; Salphati, Laurent; Hop, Cornelis E.C.A.; Rowbottom, Christopher; Xiao, Guangqing; Lai, Yurong; Mathias, Anita; Chu, Xiaoyan; Humphreys, W. Griffith; Liao, Mingxiang; Chen, Laigao; Tóth, Beáta; Juhasz, Viktoria; Heyward, Scott; Unadkat, Jashvant Journal: Drug metabolism and pharmacokinetics Issue: Volume 34:Issue 1(2019)Supplement Page Start: S22 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. Combining "Bottom‐up" and "Top‐down" Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC‐0941) Pharmacokinetics. (17th October 2017) Authors: Lu, Tong; Fraczkiewicz, Grazyna; Salphati, Laurent; Budha, Nageshwar; Dalziel, Gena; Smelick, Gillian S.; Morrissey, Kari M.; Davis, John D.; Jin, Jin Y.; Ware, Joseph A. Journal: CPT: pharmacometrics & systems pharmacology Issue: Volume 6:Number 11(2017) Page Start: 747 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
5. Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI. Issue 1 (16th September 2019) Authors: Jones, Nicholas S.; Yoshida, Kenta; Salphati, Laurent; Kenny, Jane R.; Durk, Matthew R.; Chinn, Leslie W. Journal: Clinical pharmacology & therapeutics Issue: Volume 107:Issue 1(2020) Page Start: 269 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
6. Correlation of tissue–plasma partition coefficients between normal tissues and subcutaneous xenografts of human tumor cell lines in mouse as a prediction tool of drug penetration in tumors. Issue 4 (18th January 2013) Authors: Poulin, Patrick; Hop, Cornelis Eca; Salphati, Laurent; Liederer, Bianca M. Journal: Journal of pharmaceutical sciences Issue: Volume 102:Issue 4(2013:Apr.) Page Start: 1355 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
7. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Issue 16 (15th August 2019) Authors: Bronner, Sarah M.; Merrick, Karl A.; Murray, Jeremy; Salphati, Laurent; Moffat, John G.; Pang, Jodie; Sneeringer, Christopher J.; Dompe, Nicholas; Cyr, Patrick; Purkey, Hans; Boenig, Gladys de Leon; Li, Jun; Kolesnikov, Aleksandr; Larouche-Gauthier, Robin; Lai, Kwong Wah; Shen, Xiaoli; Aubert-Nic... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 29:Issue 16(2019) Page Start: 2294 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
8. Determination of GDC‐0980 (apitolisib), a small molecule dual phosphatidylinositide 3‐kinase/mammalian target of rapamycin inhibitor in dog plasma by LC‐MS/MS to support a GLP toxicology study. (10th February 2015) Authors: Ding, Xiao; Salphati, Laurent; Kim, Amy; Morinello, Eric; Wong, Lisa; Pang, Jodie; Percey, Shaundel; Meng, Min; Reuschel, Scott; Dean, Brian Journal: Biomedical chromatography Issue: Volume 29:Number 8(2015:Aug.) Page Start: 1274 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
9. Does plasma membrane and total transporter abundance differ between suspended, plated, sandwich culture hepatocytes and human liver tissue?. Issue 1 (January 2019) Authors: Kumar, Vineet; Salphati, Laurent; Hop, Cornelis E.C.A.; Rowbottom, Christopher; Xiao, Guangqing; Lai, Yurong; Mathias, Anita; Chu, Xiaoyan; Humphreys, W.Griffith; Liao, Mingxiang; Chen, Laigao; Heyward, Scott; Unadkat, Jashvant Journal: Drug metabolism and pharmacokinetics Issue: Volume 34:Issue 1(2019)Supplement Page Start: S17 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
10. Growth‐rate model predicts in vivo tumor response from in vitro data. (4th July 2022) Authors: Diegmiller, Rocky; Salphati, Laurent; Alicke, Bruno; Wilson, Timothy R.; Stout, Thomas J.; Hafner, Marc Journal: CPT: pharmacometrics & systems pharmacology Issue: Volume 11:Number 9(2022) Page Start: 1183 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗