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Author/Creator Lavreysen, Hilde

1. Efficacy of mGlu2‐positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures. (6th February 2017)

Authors:
Metcalf, Cameron S.; Klein, Brian D.; Smith, Misty D.; Pruess, Tim; Ceusters, Marc; Lavreysen, Hilde; Pype, Stefan; Van Osselaer, Nancy; Twyman, Roy; White, H. Steve
Journal:
Epilepsia
Issue:
Volume 58:issue 3(2017)
Page Start:
484
Record Type:
Journal Article
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2. Preliminary investigation of 6, 7-dihydropyrazolo[1, 5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia. Issue 2 (15th January 2016)

Authors:
Conde-Ceide, Susana; Alcázar, Jesús; Alonso de Diego, Sergio A.; López, Silvia; Martín-Martín, María Luz; Martínez-Viturro, Carlos M.; Pena, Miguel-Angel; Tong, Han Min; Lavreysen, Hilde; Mackie, Claire; Bridges, Thomas M.; Daniels, J. Scott; Niswender, Colleen M.; Jones, Carrie K.; Macdonald, Gr...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 2(2016)
Page Start:
429
Record Type:
Journal Article
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4. Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2–positive allosteric modulator JNJ‐46356479 and levetiracetam in the mouse 6‐Hz (44‐mA) model. (23rd January 2018)

Authors:
Metcalf, Cameron S.; Klein, Brian D.; Smith, Misty D.; Ceusters, Marc; Lavreysen, Hilde; Pype, Stefan; Van Osselaer, Nancy; Twyman, Roy; White, H. Steve
Journal:
Epilepsia
Issue:
Volume 59:issue 3(2018)
Page Start:
724
Record Type:
Journal Article
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5. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222. (13th January 2016)

Authors:
Doornbos, Maarten L J; Pérez‐Benito, Laura; Tresadern, Gary; Mulder‐Krieger, Thea; Biesmans, Ilse; Trabanco, Andrés A; Cid, Jose María; Lavreysen, Hilde; IJzerman, Adriaan P; Heitman, Laura H
Journal:
British journal of pharmacology
Issue:
Volume 173:Number 3(2016:Feb.)
Page Start:
588
Record Type:
Journal Article
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6. Acyl dihydropyrazolo[1, 5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators. Issue 22 (15th November 2015)

Authors:
Malosh, Chrysa; Turlington, Mark; Bridges, Thomas M.; Rook, Jerri M.; Noetzel, Meredith J.; Vinson, Paige N.; Steckler, Thomas; Lavreysen, Hilde; Mackie, Claire; Bartolomé-Nebreda, José M.; Conde-Ceide, Susana; Martínez-Viturro, Carlos M.; Piedrafita, María; Sánchez-Casado, M. Rosa; Macdonald, Gr...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 22(2015)
Page Start:
5115
Record Type:
Journal Article
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7. Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Issue 6 (15th March 2015)

Authors:
Martín-Martín, María Luz; Bartolomé-Nebreda, José Manuel; Conde-Ceide, Susana; Alonso de Diego, Sergio A.; López, Silvia; Martínez-Viturro, Carlos M.; Tong, Han Min; Lavreysen, Hilde; Macdonald, Gregor J.; Steckler, Thomas; Mackie, Claire; Bridges, Thomas M.; Daniels, J. Scott; Niswender, Colleen...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 6(2015)
Page Start:
1310
Record Type:
Journal Article
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8. Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound. Issue 17 (1st September 2015)

Authors:
Zhou, Ya; Malosh, Chrysa; Conde-Ceide, Susana; Martínez-Viturro, Carlos Manuel; Alcázar, Jesus; Lavreysen, Hilde; Mackie, Claire; Bridges, Thomas M.; Daniels, J. Scott; Niswender, Colleen M.; Jones, Carrie K.; Macdonald, Gregor J.; Steckler, Thomas; Conn, P. Jeffrey; Stauffer, Shaun R.; Bartolomé...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 17(2015)
Page Start:
3515
Record Type:
Journal Article
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10. Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Issue 6 (15th March 2015)

Authors:
Martín-Martín, María Luz; Bartolomé-Nebreda, José Manuel; Conde-Ceide, Susana; Alonso de Diego, Sergio A.; López, Silvia; Martínez-Viturro, Carlos M.; Tong, Han Min; Lavreysen, Hilde; Macdonald, Gregor J.; Steckler, Thomas; Mackie, Claire; Bridges, Thomas M.; Daniels, J. Scott; Niswender, Colleen...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 6(2015)
Page Start:
1310
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗