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Author/Creator Lavreysen, Hilde

1. Acyl dihydropyrazolo[1, 5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators. Issue 22 (15th November 2015)

Authors:
Malosh, Chrysa; Turlington, Mark; Bridges, Thomas M.; Rook, Jerri M.; Noetzel, Meredith J.; Vinson, Paige N.; Steckler, Thomas; Lavreysen, Hilde; Mackie, Claire; Bartolomé-Nebreda, José M.; Conde-Ceide, Susana; Martínez-Viturro, Carlos M.; Piedrafita, María; Sánchez-Casado, M. Rosa; Macdonald, Gr...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 22(2015)
Page Start:
5115
Record Type:
Journal Article
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2. Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Issue 6 (15th March 2015)

Authors:
Martín-Martín, María Luz; Bartolomé-Nebreda, José Manuel; Conde-Ceide, Susana; Alonso de Diego, Sergio A.; López, Silvia; Martínez-Viturro, Carlos M.; Tong, Han Min; Lavreysen, Hilde; Macdonald, Gregor J.; Steckler, Thomas; Mackie, Claire; Bridges, Thomas M.; Daniels, J. Scott; Niswender, Colleen...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 6(2015)
Page Start:
1310
Record Type:
Journal Article
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3. Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Issue 6 (15th March 2015)

Authors:
Martín-Martín, María Luz; Bartolomé-Nebreda, José Manuel; Conde-Ceide, Susana; Alonso de Diego, Sergio A.; López, Silvia; Martínez-Viturro, Carlos M.; Tong, Han Min; Lavreysen, Hilde; Macdonald, Gregor J.; Steckler, Thomas; Mackie, Claire; Bridges, Thomas M.; Daniels, J. Scott; Niswender, Colleen...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 6(2015)
Page Start:
1310
Record Type:
Journal Article
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4. Efficacy of mGlu2‐positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures. (6th February 2017)

Authors:
Metcalf, Cameron S.; Klein, Brian D.; Smith, Misty D.; Pruess, Tim; Ceusters, Marc; Lavreysen, Hilde; Pype, Stefan; Van Osselaer, Nancy; Twyman, Roy; White, H. Steve
Journal:
Epilepsia
Issue:
Volume 58:issue 3(2017)
Page Start:
484
Record Type:
Journal Article
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5. Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound. Issue 17 (1st September 2015)

Authors:
Zhou, Ya; Malosh, Chrysa; Conde-Ceide, Susana; Martínez-Viturro, Carlos Manuel; Alcázar, Jesus; Lavreysen, Hilde; Mackie, Claire; Bridges, Thomas M.; Daniels, J. Scott; Niswender, Colleen M.; Jones, Carrie K.; Macdonald, Gregor J.; Steckler, Thomas; Conn, P. Jeffrey; Stauffer, Shaun R.; Bartolomé...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 17(2015)
Page Start:
3515
Record Type:
Journal Article
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6. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222. (13th January 2016)

Authors:
Doornbos, Maarten L J; Pérez‐Benito, Laura; Tresadern, Gary; Mulder‐Krieger, Thea; Biesmans, Ilse; Trabanco, Andrés A; Cid, Jose María; Lavreysen, Hilde; IJzerman, Adriaan P; Heitman, Laura H
Journal:
British journal of pharmacology
Issue:
Volume 173:Number 3(2016:Feb.)
Page Start:
588
Record Type:
Journal Article
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7. Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor. Issue 1 (9th December 2014)

Authors:
Lavreysen, Hilde; Ahnaou, Abdellah; Drinkenburg, Wilhelmus; Langlois, Xavier; Mackie, Claire; Pype, Stefan; Lütjens, Robert; Le Poul, Emmanuel; Trabanco, Andrés A.; Nuñez, José María Cid
Journal:
Pharmacology research & perspectives
Issue:
Volume 3:Issue 1(2015:Feb.)
Page Start:
n/a
Record Type:
Journal Article
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8. Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2–positive allosteric modulator JNJ‐46356479 and levetiracetam in the mouse 6‐Hz (44‐mA) model. (23rd January 2018)

Authors:
Metcalf, Cameron S.; Klein, Brian D.; Smith, Misty D.; Ceusters, Marc; Lavreysen, Hilde; Pype, Stefan; Van Osselaer, Nancy; Twyman, Roy; White, H. Steve
Journal:
Epilepsia
Issue:
Volume 59:issue 3(2018)
Page Start:
724
Record Type:
Journal Article
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