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Author/Creator Han, Changho

1. Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists. (15th December 2022)

Authors:
Orsi, Douglas L.; Felts, Andrew S.; Rodriguez, Alice L.; Vinson, Paige N.; Cho, Hyekyung P.; Chang, Sichen; Blobaum, Anna L.; Niswender, Colleen M.; Conn, P. Jeffrey; Jones, Carrie K.; Lindsley, Craig W.; Han, Changho
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 78(2022)
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Record Type:
Journal Article
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2. Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists. (15th November 2022)

Authors:
Capstick, Rory A.; Whomble, David; Orsi, Douglas L.; Felts, Andrew S.; Rodriguez, Alice L.; Vinson, Paige N.; Chang, Sichen; Blobaum, Anna L.; Niswender, Colleen M.; Conn, P. Jeffrey; Jones, Carrie K.; Lindsley, Craig W.; Han, Changho
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 76(2022)
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Record Type:
Journal Article
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6. SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs. Issue 16 (15th August 2019)

Authors:
Chopko, Trevor C.; Han, Changho; Gregro, Alison R.; Engers, Darren W.; Felts, Andrew S.; Poslusney, Mike S.; Bollinger, Katrina A.; Morrison, Ryan D.; Bubser, Michael; Lamsal, Atin; Luscombe, Vincent B.; Cho, Hyekyung P.; Schnetz-Boutaud, Nathalie C.; Rodriguez, Alice L.; Chang, Sichen; Daniels, ...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 16(2019)
Page Start:
2224
Record Type:
Journal Article
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7. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl)thieno[2, 3-d]pyrimidine core. Issue 13 (1st July 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Engers, Julie L.; Bollinger, Katrina A.; Melancon, Bruce J.; Tarr, James C.; Han, Changho; West, Mary; Gregro, Alison R.; Lamsal, Atin; Chang, Sichen; Ajmera, Sonia; Smith, Emery; Chase, Peter; Hodder, Peter S.; Bubser, Michael; Jones, Carrie K.; Hopkins, C...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 13(2016)
Page Start:
3029
Record Type:
Journal Article
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8. Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology. Issue 11 (1st June 2017)

Authors:
Melancon, Bruce J.; Wood, Michael R.; Noetzel, Meredith J.; Nance, Kellie D.; Engelberg, Eileen M.; Han, Changho; Lamsal, Atin; Chang, Sichen; Cho, Hyekyung P.; Byers, Frank W.; Bubser, Michael; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Engers, Darren W.; Wu, Dedong; Brandon, Nic...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 11(2017)
Page Start:
2296
Record Type:
Journal Article
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9. Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2, 5-Dibenzyl-2H-pyrazolo[4, 3-c]quinolin-3(5H)-ones as positive allosteric modulators. Issue 2 (15th January 2015)

Authors:
Han, Changho; Chatterjee, Arindam; Noetzel, Meredith J.; Panarese, Joseph D.; Smith, Emery; Chase, Peter; Hodder, Peter; Niswender, Colleen; Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 2(2015)
Page Start:
384
Record Type:
Journal Article
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10. Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2, 5-Dibenzyl-2H-pyrazolo[4, 3-c]quinolin-3(5H)-ones as positive allosteric modulators. Issue 2 (15th January 2015)

Authors:
Han, Changho; Chatterjee, Arindam; Noetzel, Meredith J.; Panarese, Joseph D.; Smith, Emery; Chase, Peter; Hodder, Peter; Niswender, Colleen; Jeffrey Conn, P.; Lindsley, Craig W.; Stauffer, Shaun R.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 2(2015)
Page Start:
384
Record Type:
Journal Article
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