Generation of formaldehyde and formaldehyde-d2 for hydroxymethylations and hydroxydeuteromethylations of difluoroenolates and difluorobenzyl carbanions. Issue 36 (13th April 2022)

• Record Type: Journal Article
• Authors: Khatri, Hari R.; Han, Changho; Alkhodier, Reem A.; Adam, Amna T.; Islam, Baharul; Colby, David A.
• Is Part Of: Chemical communications. Volume 58:Issue 36(2022)
• Page Start: 5490
• Page End: 5493
• Publication Date: 2022-04-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc01518h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A method for the in situ production of formaldehyde from dimethylsulfoxide, bromine, and cesium carbonate is reported for reactions with difluoroenolates and difluorobenzyl carbanions. Abstract : A method for the in situ production of formaldehyde from dimethylsulfoxide, bromine, and cesium carbonate is reported for reactions with difluoroenolates and difluorobenzyl carbanions. This process also generates formaldehyde-d2 for the production of 2, 2-difluoro-1, 1-deuteroethanols. Mechanistic and computational studies further characterize the production of hydroxymethylated and hydroxydeuteromethylated difluorinated organic molecules.