1. A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild‐to‐moderate Alzheimer's disease. Issue 1 (23rd February 2022) Authors: Nathan, Pradeep J.; Millais, S. Babli; Godwood, Alex; Dewit, Odile; Cross, David M.; Liptrot, Janet; Ruparelia, Bharat; Jones, Stephen Paul; Bakker, Geor; Maruff, Paul T.; Light, Gregory A.; Brown, Alastair J.H.; Weir, Malcolm Peter; Congreve, Miles; Tasker, Tim Journal: Alzheimer's & dementia Issue: Volume 8:Issue 1(2022) Page Start: n/a Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Allosteric binding: structures reveal new ways to tame G protein-coupled receptors. (November 2016) Authors: Cooke, Robert; Congreve, Miles Journal: Future medicinal chemistry Issue: Volume 8:Number 17(2016) Page Start: 2005 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs. (September 2017) Authors: Congreve, Miles; Oswald, Christine; Marshall, Fiona H. Journal: Trends in pharmacological sciences Issue: Volume 38:Number 9(2017) Page Start: 837 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. Ask the Experts: Past, present and future of the rule of five. (May 2013) Authors: Baell, Jonathan; Congreve, Miles; Leeson, Paul; Abad-Zapatero, Celerino Journal: Future medicinal chemistry Issue: Volume 5:Number 7(2013) Page Start: 745 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
5. Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket. Issue 4 (24th February 2014) Authors: Saalau‐Bethell, Susanne M.; Berdini, Valerio; Cleasby, Anne; Congreve, Miles; Coyle, Joseph E.; Lock, Victoria; Murray, Christopher W.; O'Brien, M. Alistair; Rich, Sharna J.; Sambrook, Tracey; Vinkovic, Mladen; Yon, Jeff R.; Jhoti, Harren Journal: ChemMedChem Issue: Volume 9:Issue 4(2014:Apr.) Page Start: 823 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
6. Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties1. Issue 5 (13th May 2015) Authors: Christopher, John A.; Aves, Sarah J.; Brown, Jason; Errey, James C.; Klair, Suki S.; Langmead, Christopher J.; Mace, Oliver J.; Mould, Richard; Patel, Jayesh C.; Tehan, Benjamin G.; Zhukov, Andrei; Marshall, Fiona H.; Congreve, Miles Journal: MedChemComm Issue: Volume 6:Issue 5(2015:May) Page Start: 947 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
7. First‐in‐man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1‐receptor partial agonist for the treatment of dementias. Issue 7 (5th February 2021) Authors: Bakker, Charlotte; Tasker, Tim; Liptrot, Jan; Hart, Ellen P.; Klaassen, Erica S.; Prins, Samantha; van der Doef, Thalia F.; Brown, Giles A.; Brown, Alastair; Congreve, Miles; Weir, Malcolm; Marshall, Fiona H.; Cross, David M.; Groeneveld, Geert Jan; Nathan, Pradeep J. Journal: British journal of clinical pharmacology Issue: Volume 87:Issue 7(2021) Page Start: 2945 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
8. Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design. Issue 20 (15th October 2019) Authors: O'Brien, Alistair; Andrews, Stephen P.; Baig, Asma H.; Bortolato, Andrea; Brown, Alastair J.H.; Brown, Giles A.; Brown, Sue H.; Christopher, John A.; Congreve, Miles; Cooke, Robert M.; De Graaf, Chris; Errey, James C.; Fieldhouse, Charlotte; Jazayeri, Ali; Marshall, Fiona H.; Mason, Jonathan S.; ... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 29:Issue 20(2019) Page Start: Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
9. Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design. Issue 20 (15th October 2019) Authors: O'Brien, Alistair; Andrews, Stephen P.; Baig, Asma H.; Bortolato, Andrea; Brown, Alastair J.H.; Brown, Giles A.; Brown, Sue H.; Christopher, John A.; Congreve, Miles; Cooke, Robert M.; De Graaf, Chris; Errey, James C.; Fieldhouse, Charlotte; Jazayeri, Ali; Marshall, Fiona H.; Mason, Jonathan S.; ... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 29:Issue 20(2019) Page Start: Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
10. Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1‐acetylcholine receptor agonist: A randomized cross‐over trial. Issue 11 (8th May 2021) Authors: Bakker, Charlotte; Prins, Samantha; Liptrot, Jan; Hart, Ellen P.; Klaassen, Erica S.; Brown, Giles A.; Brown, Alastair; Congreve, Miles; Weir, Malcolm; Marshall, Fiona H.; Stevens, Jasper; Cross, David M.; Tasker, Tim; Nathan, Pradeep J.; Groeneveld, Geert Jan Journal: British journal of clinical pharmacology Issue: Volume 87:Issue 11(2021) Page Start: 4439 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗