Ask the Experts: Past, present and future of the rule of five. (May 2013)

• Record Type: Journal Article
• Authors: Baell, Jonathan; Congreve, Miles; Leeson, Paul; Abad-Zapatero, Celerino
• Is Part Of: Future medicinal chemistry. Volume 5:Number 7(2013)
• Page Start: 745
• Page End: 752
• Publication Date: 2013-05
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc.13.61
• Languages: English
• ISSNs: 1756-8919

Abstract

Coined in 1997, by Christopher Lipinki et al., the rule of five (Ro5) comprises a set of parameters that determine drug-likeness for oral delivery. The parameters are as follows: no more than five hydrogen bond donors (nitrogen or oxygen atoms with one or more hydrogen atoms); no more than ten hydrogen bond acceptors (nitrogen or oxygen atoms); a molecular mass less than 500 Da; and an octanol–water partition coefficient log P no greater than 5. Future Medicinal Chemistry invited a selection of leading researchers to express their views on Lipinski's Ro5, which has influenced drug design for over a decade. Their enlightening responses provide an insight into the current and future role of Ro5, and other rules of thumb, in the evolving world of medicinal chemistry.