Altered White Matter Integrity in ADHD Revealed by Meta-analysis of Tract-based Spatial Statistics. Issue 9 (July 2023)

• Record Type: Journal Article
• Authors: Cui, Jian; Wang, Zhonggang; Xu, Yinghong; Li, Ying; Yu, Hao; Ping, Liangliang; Jin, Shushu; Cheng, Yuqi; Xu, Xiufeng; Zhang, Yuebing; Zhou, Cong
• Is Part Of: Journal of attention disorders. Volume 27:Issue 9(2023)
• Page Start: 997
• Page End: 1008
• Publication Date: 2023-07
• Subjects: ADHD -- white matter -- diffusion tensor imaging -- fractional anisotropy -- tract-based spatial statistics -- meta-analysis; Attention-deficit hyperactivity disorder -- Periodicals; Attention -- Periodicals; 616.8589
• DOI: 10.1177/10870547231167499
• Languages: English
• ISSNs: 1087-0547

Abstract

Objective: We conducted an updated coordinate-based meta-analysis (CBMA) to determine the most prominent and robust white matter (WM) abnormalities in ADHD based on tract-based spatial statistics (TBSS) findings. Method: The seed-based d mapping (SDM) software was applied to compare regional fractional anisotropy (FA) alterations in ADHD. Subgroup meta-analyses in the pure ADHD without comorbidity subgroup, the children and adolescents subgroup, and the adults subgroup were also explored, respectively. Meta-regression analysis was subsequently used to examine potential correlations between demographics and FA changes. Results: Only one cluster in the splenium of corpus callosum (CC) exhibited age-related FA decrease in ADHD individuals in the pooled meta-analysis. The adults ADHD subgroup revealed two clusters with reduced FA lied in the splenium and body of CC. Conclusion: This updated CBMA confirmed the WM abnormalities in the splenium of CC in ADHD, and improved our understanding of the pathogenesis of this neurodevelopmental disorder.