Acrylamide in food: Occurrence, metabolism, molecular toxicity mechanism and detoxification by phytochemicals. (May 2023)

• Record Type: Journal Article
• Authors: Yan, Fangfang; Wang, Li; Zhao, Li; Wang, Chengming; Lu, Qun; Liu, Rui
• Is Part Of: Food and chemical toxicology. Volume 175(2023)
• Publication Date: 2023-05
• Subjects: Acrylamide -- Metabolism -- Toxicities -- Signaling pathways -- Phytochemicals; AAMA N-acetyl-S-(2-carbamoylethyl)-L-cysteine -- AAMA-sul N-acetyl-S-(2-carbamoylethyl)-L-cysteine-sulfoxide -- ACC Acetyl-CoA carboxylase -- ACR acrylamide -- AKT serine/threonine protein kinase B -- AMPK AMP-activated protein kinase -- ARE antioxidant response element -- ASC apoptosis-associated speck-like protein containing a CARD -- ATF4 activating transcription factor 4 -- ATM ataxia telangiectasia mutated -- c/EBP CCAAT enhancer binding protein -- CHOP c/EBP homologous protein -- Cy-3-glu Cyanidin-3-O-glucoside -- EGCG epigallocatechin-3-gallate -- eIF2α eukaryotic translation initiation factor 2α -- ERKs extracellular signal-regulated kinases -- ERS endoplasmic reticulum stress -- GA glycidamide -- GAMA N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine -- GAMA-sul N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine-sulfoxide -- GRP78 glucose regulated proteins 78 -- GSH glutathione -- GSK-3β glycogen synthase kinase-3β -- IKK IκB kinase -- IL interleukin -- iNOS inducible nitric oxide synthase -- IRE1 inositol requiring enzyme 1 -- IRS insulin receptor substrate -- iso-GAMA N-acetyl-S-(1-carbamoyl-2-hydroxyethyl)-L-cysteine -- IκB inhibitor of NF-κB -- JNKs c-Jun amino-terminal kinases -- Keap1 Kelch-like ECH-associated protein 1 -- LA α-lipoic acid -- LC3 light chain 3 -- LOQ limit of quantification -- LPS lipopolysaccharide -- MAPKs mitogen-activated protein kinases -- MLCK myosin light chain kinase -- mTOR mammalian target of rapamycin -- MyD88 myeloid differentiation factor 88 -- N1-GA-Ade N1-(2-carbomyl-2-hydroxyethyl) adenine -- N3-GA-Ade N3-(2-carbomyl-2-hydroxyethyl) adenine -- N7-GA-Gua N7-(2-carbomyl-2-hydroxyethyl) guanine -- NF-κB nuclear factor-kappa B -- NLRP3 NLR family pyrin domain containing 3 -- Nrf2 nuclear factor erythroid 2-related factor 2 -- PERK protein kinase RNA-like endoplasmic reticulum kinase -- PI3K phosphatidylinositol 3-kinase -- ROS reactive oxygen species -- S1P sphingosine 1-phosphate -- SCFAs short-chain fatty acids -- SREBP sterol regulatory element binding protein -- TLR4 toll-like receptor 4 -- TNF-α tumor necrosis factor α -- TQ thymoquinone -- TRAF2 TNF receptor associated factor 2 -- UPR unfolded protein response -- ZO-1 zonula occluden-1; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2023.113696
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Acrylamide (ACR) is a common pollutant formed during food thermal processing such as frying, baking and roasting. ACR and its metabolites can cause various negative effects on organisms. To date, there have been some reviews summarizing the formation, absorption, detection and prevention of ACR, but there is no systematic summary on the mechanism of ACR-induced toxicity. In the past five years, the molecular mechanism for ACR-induced toxicity has been further explored and the detoxification of ACR by phytochemicals has been partly achieved. This review summarizes the ACR level in foods and its metabolic pathways, as well as highlights the mechanisms underlying ACR-induced toxicity and ACR detoxification by phytochemicals. It appears that oxidative stress, inflammation, apoptosis, autophagy, biochemical metabolism and gut microbiota disturbance are involved in various ACR-induced toxicities. In addition, the effects and possible action mechanisms of phytochemicals, including polyphenols, quinones, alkaloids, terpenoids, as well as vitamins and their analogs on ACR-induced toxicities are also discussed. This review provides potential therapeutic targets and strategies for addressing various ACR-induced toxicities in the future. Graphical abstract: Image 1 Highlights: The acrylamide level in foods and its new metabolites in the body were summarized. The molecular mechanism for acrylamide-induced toxicity was updated. AcRylamide detoxification by phytochemicals was reviewed.