Safety evaluation of Balanced Health Care Dan—A medicinal formulation containing traditional edible ingredients in lung tumor‐loaded mice. Issue 3 (21st December 2022)

• Record Type: Journal Article
• Authors: Dong, Feng; Zhao, Changhui; He, Xiaoyun; Dong, Yueyang; Liu, Haiyan; Yao, Peng; Xu, Wentao
• Is Part Of: Food science & nutrition. Volume 11:Issue 3(2023)
• Page Start: 1544
• Page End: 1552
• Publication Date: 2022-12-21
• Subjects: cancer -- medicinal food -- safety evaluation -- toxicological assessment; Food industry and trade -- Periodicals; Food -- Periodicals; Nutrition -- Periodicals; 664
• DOI: 10.1002/fsn3.3195
• Languages: English
• ISSNs: 2048-7177

Abstract

Abstract: Chinese formulation‐based medicinal food has been widely used in clinical trials, but its safety is not well studied. In this research, the edible safety assessment of Balanced Health Care Dan—a formulation containing traditional edible ingredients that were initially formulated to reduce side effects for lung cancer patients—was studied in mice based on biochemical and gut microbial analyses. The experimental mice were subcutaneously loaded with lung tumor A549 cells and then administrated with Balanced Health Care Dan (200 mg/kg or 400 mg/kg b.w. in gavage feeding) for 4 weeks. The body weight, blood parameters, and pathogenic phenotype in tissues were examined. No toxicological symptom was found in experimental mice compared with the normal control. Comprehensive analyses were also conducted to evaluate intestinal microbiota that are associated with many diseases. Balanced Health Care Dan modified the gut microbiota structure in a positive way. In conclusion, the Chinese formulation‐based medicinal food has shown no toxicological effect in mice within 4 weeks of feeding experiment and has the potential to be used in clinical trials. Abstract : Chinese formulation‐based medicinal food has been widely used in clinical trials, but its safety is not well studied. The current research evaluated a medicinal food for cancer patients using biochemical and gut microbial analyses to support the use of such a formula.