Food-derived bioactive peptides: Mechanisms of action underlying inflammation and oxidative stress in the central nervous system. (October 2022)

• Record Type: Journal Article
• Authors: Galland, Fabiana; de Espindola, Juliana Santos; Lopes, Daniel Saraiva; Taccola, Milena Ferreira; Pacheco, Maria Teresa Bertoldo
• Is Part Of: Food Chemistry Advances. Volume 1(2022)
• Publication Date: 2022-10
• Subjects: Food peptides -- Bioactive peptides -- Anti-inflammatory -- Antioxidant -- Central nervous system; ABAP 2, 2'-azobis(2-amidinopropane)dihydrochloride -- ACE angiotensin-converting enzyme -- ACHR acetylcholine receptors -- ACh acetylcholine -- AChE acetylcholinesterase -- AKT serine-threonine protein kinase -- AMP responsive element-binding protein -- ARE antioxidant response element -- Bax protein pro-apoptotic -- Bcl-2 protein anti-apoptotic -- BCL-XL anti-apoptotic gene -- BDNF brain-derived neurotrophic fator (proBDN-precursor and mBDNF-mature), Caspase 3, 7, 8, cysteine-aspartic proteases -- CAT catalase -- CD11B CD68 and CD86, M1 microglial activation markers -- ChAT choline acetyltransferase -- COX-2 cyclooxygenase-2 -- CREB transcription factor cyclic -- DA dopamine -- eNOS Endothelial nitric oxide synthase -- ERK phosphorylated substrate of extracellular signal regulated kinase -- GABA γ-aminobutyric acid -- GFAP glial fibrillary acidic protein -- Glu glutamic acid -- GSH glutathione -- GSH-Px glutathione peroxidase -- GSSG oxidized glutathione -- GST glutathione S-transferase -- G6PDH glucose-6-phosphate dehydrogenase -- HDL High-density lipoprotein -- HO-1 Heme oxygenase-1 -- IL-6 IL-10, IL-12 and IL-1ß, interleukine -- iNOS inducible nitric oxide synthase -- IκB complex-associated protein -- Keap-1 kelch-like ECH-associated protein 1 -- LC-PFA Long Chain Polyunsaturated Fatty Acids -- LDL low-density lipoprotein -- MAPK and MAPKs phosphorylated mitogen-activated protein kinases -- MCP-1/CCL2 monocyte chemoattractant protein-1 -- MDA malondialdehyde -- MIP-1α macrophage inflammatory protein -- MMP mitochondrial membrane potential -- MyD88 myeloid differentiation primary response gene 88 -- NCAM neural cell adhesion molecules -- NE via CAMKII noradrenaline via Ca2+/calmodulin-dependent protein kinase -- NF-κB nuclear factor kappa B -- NGF nerve growth factor -- NO nitric oxide -- Nrf2 nuclear factor erythroid 2-related fator -- NT-3 neurotrophic factor -- PARP Poly (ADP-ribose) polymerase -- PGE-2 prostaglandin E2 -- P13K phosphatidylinositol 3-kinase -- p38 mitogen-activated protein kinases -- p53 nuclear protein -- p-JNK phosphorylated c-Jun N-terminal kinase -- p-PKA phosphorylated protein kinase A -- PINK1 PTEN-induced putative protein kinase 1 -- PSD-95 postsynaptic density -- p-Tau Phosphorylated Tau Protein -- p47phox Neutrophil cytosol factor 1 -- ROS reactive oxygen species -- sAPPß soluble amyloid precursor protein beta -- SOD superoxide dismutase -- SIRT1 Sirtuin 1 -- T-AOC total antioxidant capacity -- TNFα Tumor necrosis factor-α -- TBARS thiobarbituric acid reactive substances -- TG triglycerides -- TRL4 Toll-like receptor 4 -- TRKB tropomycin receptor kinase B -- 5HT 5-hydroxytryptamine; 664
• DOI: 10.1016/j.focha.2022.100087
• Languages: English
• ISSNs: 2772-753X

Abstract

Highlights: Anti-inflammatory and antioxidant effect of food-derived peptides in the brain. Food peptide bioactivity from in vitro brain cell culture and in vivo animal models. Regulation of neuroinflammation pathways of peptides from animal and plant sources. Abstract: There is a great interest in neuroprotective molecules capable of inhibiting the signaling, transduction and amplification of inflammatory and oxidative pathways to reverse or prevent brain cell damage and neurodegeneration. Peptides derived from food proteins represent a potential natural source for this action. Although there are several food sources and amino acid sequences that have shown promising effects, the mechanism of action on brain cells is not fully understood. Food peptides must resist digestion and be absorbed by the gastrointestinal and brain barriers. Its intact form or its metabolites must reach the brain tissue to exert action on a cellular level. It remains unknown which are the main receptors and intracellular pathways through which peptides act in inflammatory and oxidative conditions, and structure-activity relationships. This article reviews the main findings on food-derived peptides with anti-inflammatory and antioxidant bioactivity on brain cell culture and in vivo models of neurotoxicity. We highlight the main oxidative and inflammatory pathways by which food peptides interact at cellular level. The evaluation of the interaction/affinity of these food peptides with different brain cellular compounds may provide insight of possible therapeutic use or food supplement development.