Oncogenic RAS Networks Suppression: Reversibly Ionic Oligonucleotide‐Based Nanoparticles Caged microRNA‐143 Inhibit KRAS‐Mutated Colon Cancer Growth in Tumor‐Bearing Mice (Adv. Therap. 2/2023). Issue 2 (15th February 2023)

• Record Type: Journal Article
• Authors: Miyamoto, Noriko; Kawasaki, Riku; Sakuragi, Mina; Yamana, Keita; Isozaki, Hinata; Kawamura, Shogo; Akiba, Isamu; Kitade, Yukio
• Is Part Of: Advanced therapeutics. Volume 6:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-15
• Subjects: Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202370008
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract : This back cover shows a novel delivery vehicle of RNA nanoparticle (named RION miR‐143 ) for RAS‐mutated intractable cancers. Tumor‐suppressor microRNA‐143 (miR‐143) silences oncogenic KRAS networks, but it lacks a nucleic acid delivery vehicle for clinical application. This research creates the RION miR‐143 by self‐assembly of miR‐143s and demonstrates delivery functions.